@article {4582,
	title = {Synthesis of new hypoxia markers EF1 and [F-18]-EF1},
	journal = {Applied Radiation and Isotopes},
	volume = {51},
	number = {6},
	year = {1999},
	note = {ISI Document Delivery No.: 242RBTimes Cited: 23Cited Reference Count: 33},
	month = {Dec},
	pages = {643-650},
	type = {Article},
	abstract = {We report on the preparation of a hypoxia marker 2-(2-nitroimidazol-1[H]-yl)-N-(3-fluoropropyl)acetamide (EF1) and its F-18 analog, 2-(2-nitroimidazol-1[H]-yl)-N-(3-[F-18]fluoropropyl)acetamide ([F-18]-EF1). Two methods for the preparation of 3-fluoropropylamine, the EF1 side chain, are described. [F-18]-EF1 was prepared with a radiochemical yield of 2\% by nucleophilic substitution of bromine in 2-(2-nitroimidazol-1[H]-yl)-N-(3-bromopropyl) acetamide (EBrl) by carrier-added F-18 in DMSO at 120 degrees C. Our results demonstrate the preparation of clinically relevant amounts of [F-18]-EF1 for use as a non-invasive hypoxia marker with detection using positron emission tomography (PET). (C) 1999 Elsevier Science Ltd. All rights reserved.},
	keywords = {ADDUCTS, CARCINOMA, CELLS, DEPENDENCE, F-18 FLUOROMISONIDAZOLE, IMAGING TUMOR HYPOXIA, INVIVO, ischemia, NONINVASIVE ASSESSMENT, REDUCTION},
	isbn = {0969-8043},
	url = {<Go to ISI>://000082954500006},
	author = {Kachur, A. V. and Dolbier, W. R. and Evans, S. M. and Shiue, C. Y. and Shiue, G. G. and Skov, K. A. and Baird, I. R. and James, Brian R. and Li, A. R. and Roche, A. and Koch, C. J.}
}
