@article {641, title = {The synthesis, structural characterization, and in vitro anti-cancer activity of chloro(p-cymene) complexes of ruthenium(II) containing a disulfoxide ligand}, journal = {Inorganica Chimica Acta}, volume = {352}, year = {2003}, note = {ISI Document Delivery No.: 711FATimes Cited: 39Cited Reference Count: 47}, month = {Aug}, pages = {238-246}, type = {Article}, abstract = {Two diruthenium(II) complexes [RuCl2(p-cymene)](2)(mu-BESE) (1), [RuCl2(p-cymene)](2)(mu-BESP) (2), and the mononuclear salt [RuCl(p-cymene)(BESE)]PF6 (3), containing the disulfoxides BESE and BESP, were synthesized and characterized by elemental analysis, and NMR and IR spectroscopies, and were shown to contain S-bound sulfoxide groups; the disulfoxides are EtS(O)(CH2)(n) S(O)Et, where n = 2 (BESE) or 3 (BESP). Complexes 1 and 3 were also characterized by X-ray crystallography. Preliminary in vitro tests of I and 3 were conducted using the MTT assay, which measures mitochondrial dehydrogenase activity as an indication of cell viability; these complexes showed in vitro anti-cancer activity against a human mammary cancer cell line (MDA-MB-435s) with IC50 values of 360 and 55 muM, respectively. (C) 2003 Elsevier B.V. All rights reserved.}, keywords = {anti-cancer activity, arene complexes, CANCER, cell, COMPLEX, COORDINATION, crystal structures, CRYSTAL-STRUCTURE, DIMETHYL-SULFOXIDE LIGAND, DIRUTHENIUM(II), disulfoxide ligands, INHIBITION, p-Cymene complexes, RADIOSENSITIZING ACTIVITY, ruthenium complexes, SOLUTION CHEMISTRY}, isbn = {0020-1693}, url = {://000184727900029}, author = {Huxham, L. A. and Cheu, E. L. S. and Patrick, B. O. and James, Brian R.} }