@article {2681,
	title = {Scaffold-based design and synthesis of potent N-type calcium channel blockers},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {19},
	number = {22},
	year = {2009},
	note = {ISI Document Delivery No.: 509PHTimes Cited: 5Cited Reference Count: 18Zamponi, Gerald W. Feng, Zhong-Ping Zhang, Lingyun Pajouhesh, Hossein Ding, Yanbing Belardetti, Francesco Pajouhesh, Hassan Dolphin, David Mitscher, Lester A. Snutch, Terrance P.},
	month = {Nov},
	pages = {6467-6472},
	type = {Article},
	abstract = {The therapeutic agents flunarizine and lomerizine exhibit inhibitory activities against a variety of ion channels and neurotransmitter receptors. We have optimized their scaffolds to obtain more selective N-type calcium channel blockers. During this optimization, we discovered NP118809 and NP078585, two potent N-type calcium channel blockers which have good selectivity over L-type calcium channels. Upon intraperitoneal administration both compounds exhibit analgesic activity in a rodent model of inflammatory pain. NP118809 further exhibits a number of favorable preclinical characteristics as they relate to overall pharmacokinetics and minimal off-target activity including the hERG potassium channel. (C) 2009 Elsevier Ltd. All rights reserved.},
	keywords = {BRAIN, CA2+ CHANNELS, Calcium channel blocker, Diphenylmethylpiperazine, N-type, OMEGA-CONOTOXIN, PAIN, SUBUNIT},
	isbn = {0960-894X},
	url = {<Go to ISI>://000271029600045},
	author = {Zamponi, G. W. and Feng, Z. P. and Zhang, L. Y. and Pajouhesh, H. and Ding, Y. B. and Belardetti, F. and Dolphin, D. and Mitscher, L. A. and Snutch, T. P.}
}
