@article {C7CS00458C, title = {Synthetic and biosynthetic routes to nitrogen{\textendash}nitrogen bonds}, journal = {Chem. Soc. Rev.}, volume = {51}, year = {2022}, pages = {2991-3046}, publisher = {The Royal Society of Chemistry}, abstract = {The nitrogen{\textendash}nitrogen bond is a core feature of diverse functional groups like hydrazines{,} nitrosamines{,} diazos{,} and pyrazoles. Such functional groups are found in >300 known natural products. Such N{\textendash}N bond-containing functional groups are also found in significant percentage of clinical drugs. Therefore{,} there is wide interest in synthetic and enzymatic methods to form nitrogen{\textendash}nitrogen bonds. In this review{,} we summarize synthetic and biosynthetic approaches to diverse nitrogen{\textendash}nitrogen-bond-containing functional groups{,} with a focus on biosynthetic pathways and enzymes.}, doi = {10.1039/C7CS00458C}, url = {http://dx.doi.org/10.1039/C7CS00458C}, author = {He, Hai-Yan and Niikura, Haruka and Du, Yi-Ling and Ryan, Katherine S.} }