@article { ISI:000468868900010, title = {Synthesis of modified 1,5-imino-d-xylitols as ligands for lysosomal -glucocerebrosidase}, journal = {MONATSHEFTE FUR CHEMIE}, volume = {150}, number = {5, SI}, year = {2019}, month = {MAY}, pages = {831-842}, abstract = {Modified 1,5-dideoxy-1,5-imino-d-xylitol analogues with different substitution patterns involving position C-1 and/or the ring nitrogen were prepared, which were designed to serve as precursors for the preparation of iminoxylitol-based ligands and tools for the elucidation and modulation of human lysosomal -glucocerebrosidase. Biological evaluation of the synthesized glycomimetics with a series of glycoside hydrolases revealed that these substitution patterns elicit excellent -glucosidase selectivities. {[}GRAPHICS] .}, issn = {0026-9247}, doi = {10.1007/s00706-019-02427-1}, author = {Zoidl, Manuel and Wolfsgruber, Andreas and Schalli, Michael and Nasseri, Seyed A. and Weber, Patrick and Stuetz, Arnold E. and Withers, Stephen G. and Wrodnigg, Tanja M.} }