@article { ISI:000368577000002,
	title = {5-Fluoro derivatives of 4-epi-isofagomine as D-galactosidase inhibitors and potential pharmacological chaperones for G(M1)-gangliosidosis as well as Fabry{\textquoteright}s disease},
	journal = {CARBOHYDRATE RESEARCH},
	volume = {420},
	year = {2016},
	month = {FEB},
	pages = {6-12},
	abstract = {Electrophilic fluorination of an exocyclic methoxymethylene enol ether derived from N-tertbutyloxycarbonyl- 1,5-dideoxy-1,5-imino-3,4-O-isopropylidene-D-erythro-pent-2-ulose (11) provided the 5-fluoro derivative of the powerful beta-galactosidase inhibitor 4-epi-isofagomine (8). This structural alteration, in combination with N-alkylation, led to considerably improved alpha-galactosidase selectivity. New compounds may serve as leads en route to new pharmacological chaperones for Fabry{\textquoteright}s disease. (C) 2015 Elsevier Ltd. All rights reserved.},
	issn = {0008-6215},
	doi = {10.1016/j.carres.2015.10.009},
	author = {Thonhofer, Martin and Santana, Andres Gonzalez and Fischer, Roland and Gomez, Ana Torvisco and Saf, Robert and Schalli, Michael and Stuetz, Arnold E. and Withers, Stephen G.}
}
