@article { ISI:000377289100007,
	title = {The Staudinger/aza-Wittig/Grignard reaction as key step for the concise synthesis of 1-C-Alkyl-iminoalditol glycomimetics},
	journal = {CARBOHYDRATE RESEARCH},
	volume = {429},
	year = {2016},
	month = {JUN 24},
	pages = {62-70},
	abstract = {The scope of a one-pot tandem approach for the synthesis of C-1 alkyl iminoalditol derivatives with a Staudinger/aza-Wittig/Grignard cascade has been evaluated. The reaction conditions have been optimized for two azidodeoxy aldose substrates and a range of Grignard reagents. The nature of both, substrate as well as nucleophile, was found to control the stereoselectivity of the alkyl addition to the cyclic iminium intermediate at position C-1. This approach enabled the synthesis of a collection of C-alkyl iminoalditols, which were biologically evaluated as inhibitors against a set of standard glycoside hydrolases. All compounds were found to exhibit highly selective inhibition of beta-glucosidase activity. (C) 2016 Elsevier Ltd. All rights reserved.},
	issn = {0008-6215},
	doi = {10.1016/j.carres.2016.04.006},
	author = {Zoidl, Manuel and Santana, Andres Gonzalez and Torvisco, Ana and Tysoe, Christina and Siriwardena, Aloysius and Withers, Stephen G. and Wrodnigg, Tanja M.}
}
