@article { ISI:000308142900008,
	title = {Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection},
	journal = {MUCOSAL IMMUNOLOGY},
	volume = {5},
	number = {5},
	year = {2012},
	month = {SEP},
	pages = {535-543},
	abstract = {Helminth infection leads to the local proliferation and accumulation of macrophages in tissues. However, the function of macrophages during helminth infection remains unclear. SH2-containing inositol 5{\textquoteright}-phosphatase 1 (Ship1, Inpp5d) is a lipid phosphatase that has been shown to play a critical role in macrophage function. Here, we identify a critical role for Ship1 in the negative regulation of interleukin (IL)-12/23p40 production by macrophages during infection with the intestinal helminth parasite Trichuris muris. Mice with myeloid cell-specific deletion of Ship1 (Ship1(Delta LysM) mice) develop a non-protective T-helper type 1 cell response and fail to expel parasites. Ship1-deficient macrophages produce heightened levels of IL-12/23p40 in vitro and in vivo and antibody blockade of IL-12/23p40 renders Ship1(Delta LysM) mice resistant to Trichuris infection. Our results identify a critical role for the negative regulation of IL-12/23p40 production by macrophages in the development of a protective T(H)2 cell response.},
	issn = {1933-0219},
	doi = {10.1038/mi.2012.29},
	author = {Hadidi, S. and Antignano, F. and Hughes, M. R. and Wang, S. K. H. and Snyder, K. and Sammis, G. M. and Kerr, W. G. and McNagny, K. M. and Zaph, C.}
}
