@article { ISI:000266794200013,
	title = {Non-Stick Sugars: Synthesis of Difluorosugar Fluorides as Potential Glycosidase Inactivators},
	journal = {AUSTRALIAN JOURNAL OF CHEMISTRY},
	volume = {62},
	number = {6},
	year = {2009},
	note = {Symposium on Glycoscience, Chemistry and Chemical Biology, Oslo, NORWAY, 2007},
	pages = {590-599},
	abstract = {Four new difluorosugar fluorides, 2-deoxy-2,5-difluoro-alpha-L-idopyranosyl fluoride, 1,5-difluoro-D-glucopyranosyl fluoride, 1,5-difluoro-L-idopyranosyl fluoride, and 2-deoxy-1,2-difluoro-D-glucopyranosyl fluoride, were synthesized from known precursors by a radical bromination/fluoride displacement sequence, followed by deprotection. The compounds were tested as time-dependent inactivators of the beta-glucosidase from Agrobacterium sp. (Abg, EC 3.2.1.21) and, while they were shown to bind to the enzyme active site as reversible competitive inhibitors, the only time-dependent inactivation observed was traced to the presence of an extremely small amount (<0.1\%) of a highly reactive contaminating impurity.},
	issn = {0004-9425},
	doi = {10.1071/CH09223},
	author = {Rempel, Brian P. and Withers, Stephen G.}
}
