@article { ISI:000280460600017,
	title = {1-Deoxynojirimycins with dansyl capped N-substituents as probes for Morbus Gaucher affected cell lines},
	journal = {CARBOHYDRATE RESEARCH},
	volume = {345},
	number = {10, SI},
	year = {2010},
	note = {15th European Carbohydrate Symposium, Vienna, AUSTRIA, JUL 19-24, 2009},
	month = {JUL 2},
	pages = {1371-1376},
	abstract = {Cyclization by double reductive amination of D-xylo-hexos-5-ulose with methyl 6-aminohexanoate gave (methoxycarbonyl)pentyl-1-deoxynojirimycin. Reaction of the terminal carboxylic acid with N-dansyl-1,6-diaminohexane provided the corresponding chain-extended fluorescent derivative. By reaction with bis(6-dansylaminohexyl)amine, the corresponding branched di-N-dansyl compound was obtained. Both compounds are strong inhibitors of D-glucosidases and could also be shown to distinctly improve, at sub-inhibitory concentrations, the activity of beta-glucocerebrosidase in a Gaucher fibroblast (N370S) cell-line through chaperoning of the enzyme to the lysosome. (C) 2010 Elsevier Ltd. All rights reserved.},
	issn = {0008-6215},
	doi = {10.1016/j.carres.2010.04.015},
	author = {Froehlich, Richard F. G. and Furneaux, Richard H. and Mahuran, Don J. and Rigat, Brigitte A. and Stuetz, Arnold E. and Tropak, Michael B. and Wicki, Jacqueline and Withers, Stephen G. and Wrodnigg, Tanja M.}
}
