@article { ISI:000168026000009,
	title = {Synthesis of 2,6-dideoxy-2-fluoro-6-{[}F-18]-fluoro-beta-D-glucopyranosyl fluoride (2,6FGF) as a potential imaging probe for glucocerebrosidase},
	journal = {JOURNAL OF LABELLED COMPOUNDS \& RADIOPHARMACEUTICALS},
	volume = {44},
	number = {5},
	year = {2001},
	month = {APR},
	pages = {385-394},
	abstract = {We have previously synthesized 2-deoxy-2-{[}F-18]-fluoro-beta -mannosyl {[}F-18]-fluoride and shown that it behaves as a mechanism-based inhibitor of Agrobacterium sp. beta -glucosidase. In-vivo experiments indicate that this compound undergoes partial hydrolysis to produce 2-deoxy-2-fluoro-mannose, which can become phosphorylated and trapped within the cell. We now report the synthesis of another 2-fluoro glycoside which is F-18-labelled at the 6 position so that the label cannot be lost during such glycoside hydrolysis and which, further, cannot be phosphorylated. The mechanism-based glycosidase inhibitor 2,6-dideoxy-2-fluoro-6-{[}F-18]-fluoro-beta -D-glucopyranosyl fluoride (2,6FGF) was synthesized in 69\% overall chemical yield and in 9\% radiochemical yield (decay corrected) as a potential imaging probe for glycosidase.},
	issn = {0362-4803},
	doi = {10.1002/jlcr.466},
	author = {Wong, AW and ADAM, MJ and Withers, SG}
}
