@article {3060,
	title = {DESIGN AND SYNTHESIS OF ANALOGS OF IONOMYCIN},
	journal = {Canadian Journal of Chemistry-Revue Canadienne De Chimie},
	volume = {72},
	number = {6},
	year = {1994},
	note = {ISI Document Delivery No.: NV309Times Cited: 7Cited Reference Count: 34},
	month = {Jun},
	pages = {1500-1511},
	type = {Article},
	abstract = {Based on the analysis of the crystal structure of the Ca2+ salt of ionomycin and the chemical and physical data on ionomycin, a number of ionomycin analogues have been synthesized to study the structural features affecting the Ca2+ binding and transport. Compounds 2, 3, and 4 were synthesized to study the effect of additional intramolecular oxygen coordination sites on Ca2+ transport. Compounds 5a-5d were prepared to study the effect of lipid solubility on Ca2+ binding and transport. Compounds 6a-6c were prepared to study the effect of the distance between the P-diketone and the carboxyl group on Ca2+ transport. A general synthetic route to these compounds has been developed. The key reactions in this route are the consecutive regioselective alkylations of the dianion of 2,4-pentanedione with the appropriate bromides.},
	keywords = {ACID, HOST-GUEST COMPLEXATION, IONOPHORE, RESOLUTION},
	isbn = {0008-4042},
	url = {<Go to ISI>://A1994NV30900010},
	author = {Hu, Thomas Q. and Weiler, L.}
}
