@article {1234,
	title = {Efficient chemoenzymatic synthesis of ADP-D-glycero-beta-D-manno-heptose and a mechanistic study of ADP-L-glycero-D-manno-heptose 6-epimerase},
	journal = {Organic Letters},
	volume = {7},
	number = {12},
	year = {2005},
	note = {ISI Document Delivery No.: 932SSTimes Cited: 10Cited Reference Count: 21},
	month = {Jun},
	pages = {2457-2460},
	type = {Article},
	abstract = {[GRAPHICS] A chemoenzymatic synthesis of ADP-D-glycero-\&beta;-D-manno-heptose (ADP-D,D-Hep) is described in which D,D-Hep 7-phosphate is converted to ADP-D,D-Hep by two biosynthetic enzymes. This strategy allows access to the 6"-deuterated analogue, which upon incubation with the epimerase showed complete retention of the isotopic label at the 6"-position. This provides evidence for a direct oxidation mechanism in which the hydride initially transferred to the NADP(+) cofactor is subsequently returned to the same carbon in a nonstereospecific manner.},
	keywords = {biosynthesis, CARBON, D-MANNOHEPTOSE 6-EPIMERASE, EPIMERIZATION, PATHWAY},
	isbn = {1523-7060},
	url = {<Go to ISI>://000229574300042},
	author = {Read, J. A. and Ahmed, R. A. and Tanner, M. E.}
}
