My research interests bridge the areas of organometallic and organic chemistry where we prepare discrete early transition metal and lanthanide complexes for use in the atom-economic, catalytic synthesis of amines. In particular, we are interested in new approaches for the synthesis of chiral ligands for early transition metal and lanthanide complexation suitable for enantioselective transformations.
Our group has developed specialized expertise in the exploitation of easily prepared and modular amidate ligand sets. Upon complexation, the unique electronic characteristics of these ligands promote the formation of very electrophilic metal centers that display promising reactivity in both C-N (hydroamination), C-C (the direct alkylation of amines) bond formation and the ring-opening polymerization of lactones.
There are three general areas of catalysis research:
1) New N,O Chelated Organometallic Complexes for
Group 4 and Lanthanide Mediated Hydroamination Catalysis
2) New N,O Chelated Organometallic Complexes for the direct alkylation of amines (the hydroaminoalkylation reaction).
2) New N,O Chelated Organometallic Complexes for the catalytic synthesis of biodegradable polymers via ring-opening polymerization of lactones.
The fundamental research of the organometallic chemistry of these new complexes provides the foundation for the program. The motivation is the application of these complexes toward small molecule organic chemistry, in which elucidation of mechanistic detail is a key focus. Researchers involved in this work will become trained in a wide range of synthetic skills. The organometallic portions of the projects will demand development of air-sensitive handling techniques while the applications portion will build organic chemistry laboratory skills. The focus on enantioselective methodology will ensure familiarity with chiral techniques (e.g. determination of optical purity, chiral resolutions).
*Photo credit: Janis Franklin/UBC Media Group, UBC Faculty of Science