Michael Blades

Faculty Directory Header Image

Michael Blades

Profile

Research and Teaching Interests

Dr. Blades' research interests involve the development, characterization, and application of optical and mass spectroscopic methods for chemical analysis.  Currently all research projects are in collaboration with senior researchers at Michael Smith Laboratories (Robin Turner and Jamie Piret) and the Centre for Blood Research (Dana Devine).

Bioanalytical  Spectroscopy

Raman spectroscopy provides a robust, label-free and non-invasive method to measure the chemical composition of cells.  This provides fundamental information on their differentiation status that is complementary to the commonly used transcription factor and surface marker analysis.  This multidimensional direct measure of the cellular product quality has the great advantage that it can be implemented using a rapid noninvasive on-line technology

Embryonic stem cells (ESC)

Embryonic stem cells (ESC), derived from pre-implantation embryos, are defined by their ability to both self-renew and differentiate into all of the cells and tissues of a mature animal. Efforts to develop methods for in vitro culture of ESC for research or eventual therapeutic applications are hampered by the lack of rapid, nondestructive assays for distinguishing ESC from other (differentiated) cells within a growing culture. Our group has demonstrated that Coherent anti-Stokes Raman scattering (CARS) and spontaneous Raman microscopy can be used as a sensitive and nondestructive methods for identifying ESC based on selective observation of specific molecular vibrations believed to be spectroscopic markers indicating the differentiated vs undifferentiated states of such cells. Raman spectroscopy permits imaging with subcellular resolution, potentially offering a means by which chemical changes accompanying the early stages of differentiation may be associated with certain intracellular compartments (e.g., nucleus, cytoplasm, membranes). A novel exposure/collection configuration has been developed, which yields high collection efficiency and low interference from non-resonant background. 

Blood

Modern transfusion medicine relies on the safe, secure, and cost-effective delivery of donated red blood cells (RBCs). Once isolated, RBCs are suspended in a defined additive solution and stored in plastic blood bags in which, over time, they undergo chemical, physiological, and morphological changes that may have a deleterious impact on some patients. Regulations limit the storage period to 42 days and the cells do not routinely undergo analytical testing before use. In this study, we use Raman spectroscopy to interrogate stored RBCs and we identify metabolic and cell-breakdown products, such as haemoglobin and membrane fragments, that build-up in the blood bags as the cells age. Our work points the way to the development of an instrument which could quickly and easily assess the biochemical nature of stored RBC units before they are transfused.

Ultraviolet resonance Raman spectroscopy

Ultraviolet resonance Raman spectroscopy (UVRRS) has developed into a very powerful method for solution analysis and for biophysical measurements, including, for example, the measurement of protein structure and function.  A number of publications below describe the development, characterization, and application of a novel fiber-optic implementation of UVRRS, a methodology that was developed in our group.  This implementation is extremely useful for in-vitro and in-vivo studies of bio-molecules in their native environment {e.g. "Ultraviolet resonance Raman spectroscopy of locked single-stranded oligo(dA) reveals conformational implications of the locked ribose in LNA", Journal of Raman Spectroscopy  40 , 1162-1171 (2009)}.  The design improves collection efficiency and minimizes inner-filtering effects encountered in absorbing biological media by using a novel technique to fabricate probes using angled mirrors to effect collection at 90°.  This mitigates the deleterious effects of sample and matrix absorbance while at the same time increasing the effective numerical aperture of the collection fiber therefore increasing the collection efficiency.  A US patent was issued to us for this probe design.

Contact

Real name: 
Email: 
Office Room Number(s): 
Chemistry A127
Office Phone Number: 
604-822-4468
Fax Number: 
604-822-2847

Curriculum Vitae

B.Sc, St. Mary's University (1976); PhD. Alberta(G. Horlick 1981); Postdoctoral, Indiana (G.M. Hieftje, 1980-81); W.A.E. McBryde Medal, Canadian Society for Chemistry (1987); U.B.C. Killam Research Prize (1988-89), Killam Senior Fellowship (1991-92); Fisher Scientific Lecture Award, Canadian Society for Chemistry(1994); Royal Society of Chemistry Award for Analytical Spectroscopy (1996); Smiths Detection Spectroscopy Award, Canadian Spectroscopy Society (2004). Fellow of the Society for Applied Spectroscopy (2009),  Editorial Board - Analytical Chemistry (2010 -), Distinguished Service Award - Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) (2015), Editor-in-Chief, Applied Spectroscopy (2013-present )

Publications

2016

McCulloch, R. D. ; Robb, D. ; Blades, M. Development Of A Next-Generation Field-Free Atmospheric Pressure Photoionization Source For Liquid Chromatography/mass Spectrometry. Rapid Communications in Mass Spectrometry 2016, 30, 339.
Buckley, K. ; Atkins, C. G. ; Chen, D. ; Schulze, H. G. ; Devine, D. V. ; Blades, M. W. ; Turner, R. F. B. Non-Invasive Spectroscopy Of Transfusable Red Blood Cells Stored Inside Sealed Plastic Blood-Bags. Analyst 2016, in press.

2015

H. Schulze, G. ; Atkins, C. G. ; Devine, D. V. ; Blades, M. W. ; Turner, R. F. B. Fully Automated Decomposition Of Raman Spectra Into Individual Pearson's Type Vii Distributions Applied To Biological And Biomedical Samples. APPLIED SPECTROSCOPY 2015, 69, 36.
Atkins, C. G. ; Buckley, K. ; Chen, D. ; Devine, D. ; Blades, M. W. ; Turner, R. F. B. Raman Spectroscopy Of Stored Red Blood Cells: Evaluating Clinically Relevant Biochemical Markers In Donated Blood. Conference on Clinical and Biomedical Spectroscopy and Imaging IV held at the European Conferences on Biomedical Optics, 2015, 9537, 95370X.
Konorov, S. O. ; H. Schulze, G. ; Gage, B. K. ; Kieffer, T. J. ; Piret, J. M. ; Blades, M. W. ; Turner, R. F. B. Process Analytical Utility Of Raman Microspectroscopy In The Directed Differentiation Of Human Pancreatic Insulin-Positive Cells. ANALYTICAL CHEMISTRY Volume: 87 Issue: 21 Pages: 10762-10769 2015, 87, 10769.

2014

Robb, D. B. ; Brown, J. M. ; Morris, M. ; Blades, M. W. Tandem Mass Spectrometry Using The Atmospheric Pressure Electron Capture Dissociation Ion Source. ANALYTICAL CHEMISTRY 2014, 86, 4446.
Konorov, S. O. ; H. Schulze, G. ; Blades, M. W. ; Turner, R. F. B. Silicon-Gold-Silica Lamellar Structures For Sample Substrates That Provide An Internal Standard For Raman Microspectroscopy. ANALYTICAL CHEMISTRY 2014, 86, 9404.

2013

H. Schulze, G. ; Konorov, S. O. ; Piret, J. M. ; Blades, M. W. ; Turner, R. F. B. Label-Free Imaging Of Mammalian Cell Nucleoli By Raman Microspectroscopy. ANALYST 2013, 138, 3423.
Konorov, S. O. ; H. Schulze, G. ; Piret, J. M. ; Blades, M. W. ; Turner, R. F. B. Label-Free Determination Of The Cell Cycle Phase In Human Embryonic Stem Cells By Raman Microspectroscopy. ANALYTICAL CHEMISTRY 2013, 85, 8996-9002.

2012

H. Schulze, G. ; Konorov, S. O. ; Okuda, K. ; Piret, J. M. ; Blades, M. W. ; Turner, R. F. B. A Volume-Exclusion Normalization Procedure For Quantitative Raman Confocal Microspectroscopy Of Immersed Samples Applied To Human Embryonic Stem Cells. JOURNAL OF RAMAN SPECTROSCOPY 2012, 43, 360-369.
Konorov, S. O. ; Jardon, M. A. ; Piret, J. M. ; Blades, M. W. ; Turner, R. F. B. Raman Microspectroscopy Of Live Cells Under Autophagy-Inducing Conditions. ANALYST 2012, 137, 4662-4668.
Robb, D. B. ; Rogalski, J. C. ; Kast, J. ; Blades, M. W. Liquid Chromatography-Atmospheric Pressure Electron Capture Dissociation Mass Spectrometry For The Structural Analysis Of Peptides And Proteins. ANALYTICAL CHEMISTRY 2012, 84, 4221-4226.

2011

Robb, D. B. ; Rogalski, J. C. ; Kast, J. ; Blades, M. W. A New Ion Source And Procedures For Atmospheric Pressure-Electron Capture Dissociation Of Peptides. Journal of The American Society for Mass Spectrometry 2011.
Konorov, S. O. ; Blades, M. W. ; Turner, R. F. B. Non-Resonant Background Suppression By Destructive Interference In Coherent Anti-Stokes Raman Scattering Spectroscopy. Optics Express 2011, 19, 25925.
Konorov, S. O. ; H. Schulze, G. ; Atkins, C. G. ; Piret, J. M. ; Aparicio, S. A. ; Turner, R. F. B. ; Blades, M. W. Absolute Quantification Of Intracellular Glycogen Content In Human Embryonic Stem Cells With Raman Microspectroscopy. Analytical Chemistry 2011, 83, 6254 - 6258.
H. SCHULZE, G. E. O. R. G. ; Konorov, S. O. ; Aparicio, S. A. ; Piret, J. M. ; Blades, M. W. ; Turner, R. F. B. Raman Microscopy Of Human Embryonic Stem Cells Exposed To Heat And Cold Stress. Applied Spectroscopy 2011, 65, 1380 - 1386.
Konorov, S. O. ; H. Schulze, G. ; Piret, J. M. ; Turner, R. F. B. ; Blades, M. W. Evidence Of Marked Glycogen Variations In The Characteristic Raman Signatures Of Human Embryonic Stem Cells. Journal of Raman Spectroscopy 2011, 42, 1135 - 1141.
Robb, D. B. ; Rogalski, J. C. ; Kast, J. ; Blades, M. W. A New Ion Source And Procedures For Atmospheric Pressure-Electron Capture Dissociation Of Peptides. Journal of The American Society for Mass Spectrometry 2011, 22, 1699 - 1706.
Konorov, S. O. ; H. Schulze, G. ; Caron, N. J. ; Piret, J. M. ; Blades, M. W. ; Turner, R. F. B. Raman Microspectroscopic Evidence That Dry-Fixing Preserves The Temporal Pattern Of Non-Specific Differentiation In Live Human Embryonic Stem Cells. Journal of Raman Spectroscopy 2011, 42, 576 - 579.
Addison, C. J. ; Konorov, S. O. ; H. Schulze, G. ; Turner, R. F. B. ; Blades, M. W. Residual Benzamide Contamination In Synthetic Oligonucleotides Observed Using Uv Resonance Raman Spectroscopy. Journal of Raman Spectroscopy 2011, 42, 349 - 354.

2010

Robb, D. B. ; Rogalski, J. C. ; Kast, J. ; Blades, M. W. Atmospheric Pressure-Electron Capture Dissociation Of Peptides Using A Modified Photospray Ion Source. Rapid Communications in Mass Spectrometry 2010, 24, 3303 - 3308.
H. Schulze, G. ; Konorov, S. O. ; Caron, N. J. ; Piret, J. M. ; Blades, M. W. ; Turner, R. F. B. Assessing Differentiation Status Of Human Embryonic Stem Cells Noninvasively Using Raman Microspectroscopy. Analytical Chemistry 2010, 82, 5020 - 5027.
Konorov, S. O. ; H. Schulze, G. ; Caron, N. J. ; Piret, J. M. ; Blades, M. W. ; Turner, R. F. B. Raman Microspectroscopic Evidence That Dry-Fixing Preserves The Temporal Pattern Of Non-Specific Differentiation In Live Human Embryonic Stem Cells. Journal of Raman Spectroscopy 2010, 42, 576 - 579.

2009

Smith, D. R. ; Robb, D. B. ; Blades, M. W. Comparison Of Dopants For Charge Exchange Ionization Of Nonpolar Polycyclic Aromatic Hydrocarbons With Reversed-Phase Lc-Appi-Ms. Journal of the American Society for Mass Spectrometry 2009, 20, 73-79.
Konorov, S. O. ; H. Schulze, G. ; Addison, C. J. ; Haynes, C. A. ; Turner, R. F. B. ; Blades, M. W. Temperature-Dependent Excited State Absorption In Dna And Lna Oligomers Supports An Emerging Model Of Excited State Dynamics In Dna. The Open Spectroscopy Journal 2009, 3, 43 - 51.
Konorov, S. O. ; H. Schulze, G. ; Addison, C. J. ; Haynes, C. A. ; Blades, M. W. ; Turner, R. F. B. Base Stacking Configuration Is A Major Determinant Of Excited State Dynamics In A.t Dna And Lna. The Open Spectroscopy Journal 2009, 3, 9 - 20.

2008

Robb, D. B. ; Blades, M. W. State-Of-The-Art In Atmospheric Pressure Photoionization For Lc/ms. Analytica Chimica Acta 2008, 627, 34-49.
McCulloch, R. D. ; Robb, D. B. ; Blades, M. W. A Dopant Introduction Device For Atmospheric Pressure Photoionization With Liquid Chromatography/mass Spectrometry. Rapid Communications in Mass Spectrometry 2008, 22, 3549-3554.
Yu, M. M. L. ; Konorov, S. O. ; Schulze, H. G. ; Blades, M. W. ; Turner, R. F. B. ; Jetter, R. In Situ Analysis By Microspectroscopy Reveals Triterpenoid Compositional Patterns Within Leaf Cuticles Of Prunus Laurocerasus. Planta 2008, 227, 823-834.
Robb, D. B. ; Smith, D. R. ; Blades, M. W. Investigation Of Substituted-Benzene Dopants For Charge Exchange Ionization Of Nonpolar Compounds By Atmospheric Pressure Photoionization. Journal of the American Society for Mass Spectrometry 2008, 19, 955-963.

2007

Yu, M. M. L. ; Schulze, H. G. ; Jetter, R. ; Blades, M. W. ; Turner, R. F. B. Raman Microspectroscopic Analysis Of Triterpenoids Found In Plant Cuticles. Applied Spectroscopy 2007, 61, 32-37.
Konorov, S. O. ; Glover, C. H. ; Piret, J. M. ; Bryan, J. ; Schulze, H. G. ; Blades, M. W. ; Turner, R. F. B. In Situ Analysis Of Living Embryonic Stem Cells By Coherent Anti-Stokes Raman Microscopy. Analytical Chemistry 2007, 79, 7221-7225.
Konorov, S. O. ; Turner, R. F. B. ; Blades, M. W. Background-Free Coherent Anti-Stokes Raman Scattering Of Gas- And Liquid-Phase Samples In A Mesoporous Silica Aerogel Host. Applied Spectroscopy 2007, 61, 486-489.
Konorov, S. O. ; Xu, X. G. ; Turner, R. F. B. ; Blades, M. W. ; Hepburn, J. W. ; Milner, V. Pulse Optimization For Raman Spectroscopy With Cross-Correlation Frequency Resolved Optical Gating. Optics Express 2007, 15, 7564-7571.

2006

Jirasek, A. ; Matthews, Q. ; Hilts, M. ; Schulze, G. ; Blades, M. W. ; Burner, R. F. B. Investigation Of A 2D Two-Point Maximum Entropy Regularization Method For Signal-To-Noise Ratio Enhancement: Application To Ct Polymer Gel Dosimetry. Physics in Medicine and Biology 2006, 51, 2599-2617.
Robb, D. B. ; Blades, M. W. Factors Affecting Primary Ionization In Dopant-Assisted Atmospheric Pressure Photoionization (Da-Appi) For Lc/ms. Journal of the American Society for Mass Spectrometry 2006, 17, 130-138.
Jirasek, A. ; Schulze, H. G. ; Hughesman, C. H. ; Creagh, A. L. ; Haynes, C. A. ; Blades, M. W. ; Turner, R. F. B. Discrimination Between Uv Radiation-Induced And Thermally Induced Spectral Changes In At-Paired Dna Oligomers Using Uv Resonance Raman Spectroscopy. Journal of Raman Spectroscopy 2006, 37, 1368-1380.

2005

Schulze, G. ; Jirasek, A. ; Yu, M. M. L. ; Lim, A. ; Turner, R. F. B. ; Blades, M. W. Investigation Of Selected Baseline Removal Techniques As Candidates For Automated Implementation. Applied Spectroscopy 2005, 59, 545-574.
Horsman, G. P. ; Jirasek, A. ; Vaillancourt, F. H. ; Barbosa, C. J. ; Jarzecki, A. A. ; Xu, C. L. ; Mekmouche, Y. ; Spiro, T. G. ; Lipscomb, J. D. ; Blades, M. W. ; Turner, R. F. B. ; Eltis, L. D. Spectroscopic Studies Of The Anaerobic Enzyme - Substrate Complex Of Catechol 1,2-Dioxygenase. Journal of the American Chemical Society 2005, 127, 16882-16891.

2004

Jirasek, A. ; Schulze, G. ; Yu, M. M. L. ; Blades, M. W. ; Turner, R. F. B. Accuracy And Precision Of Manual Baseline Determination. Applied Spectroscopy 2004, 58, 1488-1499.

2003

Rolland, D. ; Specht, A. A. ; Blades, M. W. ; Hepburn, J. W. Resonance Enhanced Multiphoton Dissociation Of Polycyclic Aromatic Hydrocarbons Cations In An Rf Ion Trap. Chemical Physics Letters 2003, 373, 292-298.
Specht, A. A. ; Blades, M. W. Direct Determination Of Polycyclic Aromatic Hydrocarbons In Solid Matrices Using Laser Desorption/laser Photoionization Ion Trap Mass Spectrometry. Journal of the American Society for Mass Spectrometry 2003, 14, 562-570.
Schulze, G. ; Jirasek, A. ; Blades, M. W. ; Turner, R. F. B. Identification And Interpretation Of Generalized Two-Dimensional Correlation Spectroscopy Features Through Decomposition Of The Perturbation Domain. Applied Spectroscopy 2003, 57, 1561-1574.
Jirasek, A. ; Schulze, G. ; Blades, M. W. ; Turner, R. F. B. Revealing System Dynamics Through Decomposition Of The Perturbation Domain In Two-Dimensional Correlation Spectroscopy. Applied Spectroscopy 2003, 57, 1551-1560.

2002

Vaillancourt, F. H. ; Barbosa, C. J. ; Spiro, T. G. ; Bolin, J. T. ; Blades, M. W. ; Turner, R. F. B. ; Eltis, L. D. Definitive Evidence For Monoanionic Binding Of 2,3-Dihydroxybiphenyl To 2,3-Dihydroxybiphenyl 1,2-Dioxygenase From Uv Resonance Raman Spectroscopy, Uv/vis Absorption Spectroscopy, And Crystallography. Journal of the American Chemical Society 2002, 124, 2485-2496.
Barbosa, C. J. ; Vaillancourt, F. H. ; Eltis, L. D. ; Blades, M. W. ; Turner, R. F. B. The Power Distribution Advantage Of Fiber-Optic Coupled Ultraviolet Resonance Raman Spectroscopy For Bioanalytical And Biomedical Applications. Journal of Raman Spectroscopy 2002, 33, 503-510.

2001

Vaillancourt, F. H. ; Barbosa, C. J. ; Spiro, T. G. ; Blades, M. W. ; Turner, R. F. B. ; Eltis, L. D. Direct Evidence For Monoanionic Binding Of Substrate To 2,3-Dihydroxybiphenyl 1,2-Dioxygenase Probed By Uv Resonance Raman And Uv/vis Absorption Spectroscopies. Journal of Inorganic Biochemistry 2001, 86, 465-465.
Lu, S. Y. ; LeBlanc, C. W. ; Blades, M. W. Analyte Ionization In The Furnace Atomization Plasma Excitation Spectrometry Source - Spatial And Temporal Observations. Journal of Analytical Atomic Spectrometry 2001, 16, 256-262.
Bass, A. ; Chevalier, C. ; Blades, M. W. A Capacitively Coupled Microplasma (Cc Mu P) Formed In A Channel In A Quartz Wafer. Journal of Analytical Atomic Spectrometry 2001, 16, 919-921.

2000

Cha, B. C. ; Blades, M. W. ; Douglas, D. J. An Interface With A Linear Quadrupole Ion Guide For An Electrospray-Ion Trap Mass Spectrometer System. Analytical Chemistry 2000, 72, 5647-5654.
Rahman, M. M. ; Blades, M. W. Effects From Easily Ionized Elements On Silver Analyte In Atmospheric Pressure Parallel Plate Capacitively Coupled Plasma (Pp-Ccp). Spectrochimica Acta Part B-Atomic Spectroscopy 2000, 55, 327-338.
Rahman, M. M. ; Blades, M. W. Ionization Of Mg And Cd In An Atmospheric Pressure Parallel Plate Capacitively Coupled Plasma. Journal of Analytical Atomic Spectrometry 2000, 15, 1313-1319.

1999

Schulze, H. G. ; Greek, L. S. ; Barbosa, C. J. ; Blades, M. W. ; Gorzalka, B. B. ; Turner, R. F. B. Measurement Of Some Small-Molecule And Peptide Neurotransmitters In-Vitro Using A Fiber-Optic Probe With Pulsed Ultraviolet Resonance Raman Spectroscopy. Journal of Neuroscience Methods 1999, 92, 15-24.
Robb, D. B. ; Blades, M. W. Optimum Phase Angle For Laser Desorption Ion Trap Mass Spectrometry Is Dependent On The Number Of Ions Produced. International Journal of Mass Spectrometry 1999, 191, 69-80.

1998

Schulze, H. G. ; Greek, L. S. ; Barbosa, C. J. ; Blades, M. W. ; Turner, R. F. B. Signal Detection For Data Sets With A Signal-To-Noise Ratio Of 1 Or Less With The Use Of A Moving Product Filter. Applied Spectroscopy 1998, 52, 621-625.

1997

Rahman, M. M. ; Blades, M. W. Atmospheric Pressure, Radio Frequency, Parallel Plate Capacitively Coupled Plasma - Excitation Temperatures And Analytical Figures Of Merit. Spectrochimica Acta Part B-Atomic Spectroscopy 1997, 52, 1983-1993.
LeBlanc, C. W. ; Blades, M. W. Spatial And Temporal Profiles Of Indium In A Furnace Atomization Plasma Excitation Spectrometry Source. Applied Spectroscopy 1997, 51, 1715-1721.
Robb, D. ; Blades, M. W. Electrodeposited Polythiophene Films Provide Reproducible Samples For Laser Desorption Ion Trap Mass Spectrometry Studies. Journal of the American Society for Mass Spectrometry 1997, 8, 1203-1205.

1996

Weir, D. G. ; Blades, M. W. Characteristics Of An Inductively Coupled Argon Plasma Operating With Organic Aerosols .4. Noise Power Spectra. Journal of Analytical Atomic Spectrometry 1996, 11, 1011-1018.
Greek, L. S. ; Schulze, H. G. ; Haynes, C. A. ; Blades, M. W. ; Turner, R. F. B. Rational Design Of Fiber-Optic Probes For Visible And Pulsed-Ultraviolet Resonance Raman Spectroscopy. Applied Optics 1996, 35, 4086-4095.

1995

Schulze, H. G. ; Greek, L. S. ; Gorzalka, B. B. ; Bree, A. V. ; Blades, M. W. ; Turner, R. F. B. Artificial Neural-Network And Classical Least-Squares Methods For Neurotransmitter Mixture Analysis. Journal of Neuroscience Methods 1995, 56, 155-167.
Greek, L. S. ; Schulze, H. G. ; Blades, M. W. ; Bree, A. V. ; Gorzalka, B. B. ; Turner, R. F. B. Snr Enhancement And Deconvolution Of Raman-Spectra Using A 2-Point Entropy Regularization Method. Applied Spectroscopy 1995, 49, 425-431.
LeBlanc, C. W. ; Blades, M. W. Spatially Resolved Temperature Measurements In A Furnace Atomization Plasma Excitation Spectrometry Source. Spectrochimica Acta Part B-Atomic Spectroscopy 1995, 50, 1395-1408.

1994

Blades, M. W. Atomic Mass-Spectrometry. Applied Spectroscopy 1994, 48, A12-A18.
Blades, M. W. Atmospheric-Pressure, Radio-Frequency, Capacitively Coupled Helium Plasmas. Spectrochimica Acta Part B-Atomic Spectroscopy 1994, 49, 47-57.
Schulze, H. G. ; Blades, M. W. ; Bree, A. V. ; Gorzalka, B. B. ; Greek, L. S. ; Turner, R. F. B. Characteristics Of Backpropagation Neural Networks Employed In The Identification Of Neurotransmitter Raman-Spectra. Applied Spectroscopy 1994, 48, 50-57.
Weir, D. G. ; Blades, M. W. Characteristics Of An Inductively-Coupled Argon Plasma Operating With Organic Aerosols .1. Spectral And Spatial Observations. Journal of Analytical Atomic Spectrometry 1994, 9, 1311-1322.

1993

Hettipathirana, T. D. ; Blades, M. W. Furnace Atomization Plasma Excitation Spectrometry - Effects Of Sodium-Chloride And Sodium-Nitrate On Lead And Silver Emission. Journal of Analytical Atomic Spectrometry 1993, 8, 955-959.
Gill, C. G. ; Blades, M. W. Laser Ablation Ion-Trap Mass-Spectrometry - Atomic And Molecular Mass-Spectrometry Of Metal, Ceramic And Polymer Samples. Journal of Analytical Atomic Spectrometry 1993, 8, 261-267.

1992

Banks, P. R. ; Blades, M. W. An Investigation Of Directed Support Gas-Flows For The Improvement Of Sampling Efficiency In Glow-Discharges. Spectrochimica Acta Part B-Atomic Spectroscopy 1992, 47, 1203-1220.
Banks, P. R. ; Blades, M. W. Atomic Excitation In A Jet-Assisted Glow-Discharge Plasma Plume. Spectrochimica Acta Part B-Atomic Spectroscopy 1992, 47, 1287-1307.
Hettipathirana, T. D. ; Blades, M. W. Temporal Emission And Absorption Characteristics Of Silver, Lead And Manganese In Furnace Atomization Plasma Excitation Spectrometry. Journal of Analytical Atomic Spectrometry 1992, 7, 1039-1046.
Banks, P. R. ; Blades, M. W. Comparisons Between A Grimm-Type Glow-Discharge And A Jet-Assisted Glow-Discharge Source Viewed Axially And Laterally. Spectrochimica Acta Part B-Atomic Spectroscopy 1992, 47, 1435-1446.
Hettipathirana, T. D. ; Blades, M. W. Furnace Atomization Plasma Excitation Spectroscopy - Spectral, Spatial, And Temporal Characteristics. Spectrochimica Acta Part B-Atomic Spectroscopy 1992, 47, 493-503.

1991

Blades, M. W. ; Banks, P. ; Gill, C. ; Huang, D. G. ; Leblanc, C. ; Liang, D. Application Of Weakly Ionized Plasmas For Materials Sampling And Analysis. Ieee Transactions on Plasma Science 1991, 19, 1090-1113.
Huang, D. G. ; Blades, M. W. Evaluation Of A 13.56 Mhz Capacitively Coupled Plasma As A Detector For Gas-Chromatographic Determination Of Organotin Compounds. Journal of Analytical Atomic Spectrometry 1991, 6, 215-219.
Gill, C. G. ; Daigle, B. ; Blades, M. W. Atomic Mass-Spectrometry Of Solid Samples Using Laser Ablation-Ion Trap Mass-Spectrometry (Laitms). Spectrochimica Acta Part B-Atomic Spectroscopy 1991, 46, 1227-1235.
Burton, L. L. ; Blades, M. W. Charge-Transfer Between Ar And Mg In An Inductively Coupled Plasma. Spectrochimica Acta Part B-Atomic Spectroscopy 1991, 46, 819-830.
Banks, P. R. ; Blades, M. W. Power, Flow-Rate, And Pressure Effects In A Jet-Assisted Glow-Discharge Source. Spectrochimica Acta Part B-Atomic Spectroscopy 1991, 46, 501-515.
Huang, D. G. ; Blades, M. W. Characterization Of An Atmospheric-Pressure Parallel-Plate Capacitively Coupled Radiofrequency Plasma. Applied Spectroscopy 1991, 45, 1468-1477.

1990

Leblanc, C. ; Blades, M. W. Spatially Resolved Laser-Induced Fluorescence Studies On A 3-Electrode Direct-Current Plasma. Journal of Analytical Atomic Spectrometry 1990, 5, 99-107.
Smith, D. L. ; Liang, D. C. ; Steel, D. ; Blades, M. W. Analytical Characteristics Of Furnace Atomization Plasma Excitation Spectrometry (Fapes). Spectrochimica Acta Part B-Atomic Spectroscopy 1990, 45, 493-498.
Hettipathirana, T. D. ; Wade, A. P. ; Blades, M. W. Effects Of Organic-Acids In Low-Power Inductively Coupled Argon Plasma-Optical Emission-Spectroscopy. Spectrochimica Acta Part B-Atomic Spectroscopy 1990, 45, 271-280.
Weir, D. G. J. ; Blades, M. W. An Electronic Device For Control Of Solvent-Plasma Load For Inductively Coupled Plasma Spectroscopy. Spectrochimica Acta Part B-Atomic Spectroscopy 1990, 45, 615-618.
Burton, L. L. ; Blades, M. W. A Simple Method For Calculating Deviations From Local Thermodynamic-Equilibrium In The Inductively Coupled Plasma. Spectrochimica Acta Part B-Atomic Spectroscopy 1990, 45, 139-144.

1989

Huang, D. G. ; Liang, D. C. ; Blades, M. W. Capacitively Coupled Plasma Detector For Gas-Chromatography. Journal of Analytical Atomic Spectrometry 1989, 4, 789-791.
Liang, D. C. ; Blades, M. W. An Atmospheric-Pressure Capacitively Coupled Plasma Formed Inside A Graphite-Furnace As A Source For Atomic Emission-Spectroscopy. Spectrochimica Acta Part B-Atomic Spectroscopy 1989, 44, 1059-1063.
Liang, D. C. ; Blades, M. W. Atmospheric-Pressure Capacitively Coupled Plasma Spectral Lamp And Source For The Direct Analysis Of Conducting Solid Samples. Spectrochimica Acta Part B-Atomic Spectroscopy 1989, 44, 1049-1057.
Banks, P. R. ; Blades, M. W. Atomic Emission-Spectroscopy Using A Jet-Assisted Glow-Discharge Source. Spectrochimica Acta Part B-Atomic Spectroscopy 1989, 44, 1117-1124.

1988

Hauser, P. C. ; Blades, M. W. Atomization Of Organic-Compounds In The Inductively Coupled Plasma. Applied Spectroscopy 1988, 42, 595-598.
Paski, E. F. ; Blades, M. W. Analysis Of Inorganic Powders By Time Wavelength Resolved Luminescence Spectroscopy. Analytical Chemistry 1988, 60, 1224-1230.
Liang, D. C. ; Blades, M. W. Atmospheric-Pressure Capacitively Coupled Plasma Atomizer For Atomic-Absorption Spectrometry. Analytical Chemistry 1988, 60, 27-31.
Wirsz, D. F. ; Blades, M. W. Automatic Matrix Dependent Wavelength Selection In Inductively Coupled Plasma Atomic Emission-Spectrometry With Multi-Line Detection. Journal of Analytical Atomic Spectrometry 1988, 3, 363-373.
Burton, L. L. ; Blades, M. W. Computer-Simulation Of Spectral Interferences In Inductively Coupled Plasma-Optical Emission-Spectroscopy. Spectrochimica Acta Part B-Atomic Spectroscopy 1988, 43, 305-315.
Blades, M. W. Fundamental Reference Data And The Inductively Coupled Plasma. Spectrochimica Acta Part B-Atomic Spectroscopy 1988, 43, 35-43.
Horner, J. A. ; Wade, A. P. ; Blades, M. W. Automated Flow-Injection Evaluation Of Interferences And Matrix Effects For Inductively Coupled Plasma Atomic Emission-Spectrometry. Journal of Analytical Atomic Spectrometry 1988, 3, 809-814.

1987

Wirsz, D. F. ; Browne, R. J. ; Blades, M. W. Dynamic-Range Enhancement Of Photodiode Array Spectra. Applied Spectroscopy 1987, 41, 1383-1387.
Caughlin, B. L. ; Blades, M. W. Effect Of Wet And Dry Nebulizer Gas On The Spatial-Distribution Of Electron-Density. Spectrochimica Acta Part B-Atomic Spectroscopy 1987, 42, 353-360.
Faggetter, B. ; Heisz, G. ; Blades, M. W. The Electronic Partition-Functions Of Lanthanide Atoms And Ions Between 1500-K And 8000-K. Spectrochimica Acta Part B-Atomic Spectroscopy 1987, 42, 1235-1236.
Blades, M. W. ; Caughlin, B. L. ; Walker, Z. H. ; Burton, L. L. Excitation, Ionization, And Spectral-Line Emission In The Inductively Coupled Plasma. Progress in Analytical Spectroscopy 1987, 10, 57-109.
Burton, L. L. ; Blades, M. W. Influence Of Instrumental Broadening On Lineshapes Detected By Pmt And Photodiode Array Detectors. Spectrochimica Acta Part B-Atomic Spectroscopy 1987, 42, 513-519.
Walker, Z. ; Blades, M. W. The Rf Input Power Dependence Of Chromium Excited-State Level Populations In The Inductively Coupled Plasma. Spectrochimica Acta Part B-Atomic Spectroscopy 1987, 42, 1077-1083.

1986

Burton, L. L. ; Blades, M. W. Computer-Simulation Of Emission From Analyte Atoms And Ions Excited In An Inductively Coupled Plasma. Spectrochimica Acta Part B-Atomic Spectroscopy 1986, 41, 1063-1074.
Walker, Z. ; Blades, M. W. Measurement Of Excited-State Level Populations For Atomic And Ionic Iron In The Inductively Coupled Plasma. Spectrochimica Acta Part B-Atomic Spectroscopy 1986, 41, 761-775.

1985

Caughlin, B. L. ; Blades, M. W. Analyte Ionization In The Inductively Coupled Plasma. Spectrochimica Acta Part B-Atomic Spectroscopy 1985, 40, 1539-1554.
Blades, M. W. ; Caughlin, B. L. Excitation Temperature And Electron-Density In The Inductively Coupled Plasma Aqueous Vs Organic-Solvent Introduction. Spectrochimica Acta Part B-Atomic Spectroscopy 1985, 40, 579-591.
Hauser, P. C. ; Blades, M. W. On The Determination Of Oxygen In Organic-Solvents Using An Inductively Coupled Plasma. Applied Spectroscopy 1985, 39, 872-877.
Caughlin, B. L. ; Blades, M. W. Spatial Profiles Of Electron-Density In The Inductively Coupled Plasma. Spectrochimica Acta Part B-Atomic Spectroscopy 1985, 40, 987-993.

1984

Carr, J. W. ; Blades, M. W. Emission-Spectra Of A Direct-Current Plasma In The Vacuum Ultraviolet Spectral Region From 100 To 200 Nm. Spectrochimica Acta Part B-Atomic Spectroscopy 1984, 39, 667-675.
Carr, J. W. ; Blades, M. W. Emission-Spectra Of An Argon Inductively Coupled Plasma In The Vacuum Ultraviolet - Background Spectra From 85 To 200 Nm. Spectrochimica Acta Part B-Atomic Spectroscopy 1984, 39, 567-574.
Caughlin, B. L. ; Blades, M. W. An Evaluation Of Ion-Atom Emission Intensity Ratios And Local Thermodynamic-Equilibrium In An Argon Inductively Coupled Plasma. Spectrochimica Acta Part B-Atomic Spectroscopy 1984, 39, 1583-1602.
Blades, M. W. ; Hauser, P. Quantitation Of Sulfur In Xylene With An Inductively-Coupled Plasma Photodiode-Array Spectrometer. Analytica Chimica Acta 1984, 157, 163-169.
Blades, M. W. ; Lee, N. A Spatial Study Of Electron-Density And Analyte Emission In A Dc Argon Plasma. Spectrochimica Acta Part B-Atomic Spectroscopy 1984, 39, 879-890.

1983

1982

Blades, M. W. Some Considerations Regarding Temperature, Electron-Density, And Ionization In The Argon Inductively Coupled Plasma. Spectrochimica Acta Part B-Atomic Spectroscopy 1982, 37, 869-879.