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Unimolecular Micelles based on Hydrophobically Derivatized Hyperbranched Polyglycerols: Biodistribution Studies

TitleUnimolecular Micelles based on Hydrophobically Derivatized Hyperbranched Polyglycerols: Biodistribution Studies
Publication TypeJournal Article
Year of Publication2008
AuthorsKainthan, RK, Brooks, DE
JournalBioconjugate Chemistry
Volume19
Pagination2231-2238
Date PublishedNov
Type of ArticleArticle
ISBN Number1043-1802
KeywordsALBUMIN, BIOLOGICAL EVALUATION, DENDRIMERS, IMMUNOGENICITY, IN-VIVO, LIPOSOMES, MOLECULAR-WEIGHT, POLYETHYLENE-GLYCOL DEGRADATION, POLYMERS, STARCH
Abstract

We recently reported the synthesis and testing of a new class of unimolecular micelles based on hyperbranched polyglycerols as second generation synthetic plasma expanders and as general drug delivery vehicles. A detailed biodistribution study of two derivatized hyperbranched polyglycerols of different molecular weights derivatized with hydrophobic groups and short poly(ethylene glycol) chains is reported in this article. In mice, these materials are nontoxic with circulation half-lives as high as 31 h, controllable by manipulating the molecular weight and the degree of PEG derivatization. Organ accumulation is low, presumably due to the "pegylation" effect. Thermal degradation and hydrolysis data suggest that these polymers are highly stable with a long shelf life, a major advantage for a pharmaceutical product. Degradation under acidic conditions has been observed for these polymers.

URL<Go to ISI>://000261001800018