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Uncialamycin, a new enediyne antibiotic

TitleUncialamycin, a new enediyne antibiotic
Publication TypeJournal Article
Year of Publication2005
AuthorsDavies, J, Wang, H, Taylor, T, Warabi, K, Huang, XH, Andersen, RJ
JournalOrganic Letters
Volume7
Pagination5233-5236
Date PublishedNov
Type of ArticleArticle
ISBN Number1523-7060
KeywordsCALICHEAMICIN, DYNEMICIN-A, resistance
Abstract

Laboratory cultures of an undescribed streptomycete obtained from the surface of a British Columbia lichen produce uncialamycin (1), a new enediyne antibiotic. The structure of uncialamycin (1) has been elucidated by analysis of spectroscopic data. Uncialamycin (1) exhibits potent in vitro antibacterial activity against Gram-positive and Gram-negative human pathogens, including Burkholderia cepacia, a major cause of morbidity and mortality in patients with cystic fibrosis.

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