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Tupuseleiamides and basiliskamides, new acyldipeptides and antifungal polyketides produced in culture by a Bacillus laterosporus isolate obtained from a tropical marine habitat

TitleTupuseleiamides and basiliskamides, new acyldipeptides and antifungal polyketides produced in culture by a Bacillus laterosporus isolate obtained from a tropical marine habitat
Publication TypeJournal Article
Year of Publication2002
AuthorsBarsby, T, Kelly, MT, Andersen, RJ
JournalJournal of Natural Products
Volume65
Pagination1447-1451
Date PublishedOct
Type of ArticleArticle
ISBN Number0163-3864
KeywordsANTIBIOTIC-RESISTANCE, BACTERIUM, MICROORGANISMS, NATURAL-PRODUCTS, STEREOCHEMISTRY, YM-47522
Abstract

Laboratory cultures of PNG 276, a Bacillus laterosporus isolate obtained from coastal waters off Papua New Guinea, have been shown to produce the novel metabolites basiliskamide A (1), basiliskamide B (2), tupuseleiamide A (3), and tupusleiamide B (4). The structures of I to 4 were elucidated by analysis of spectroscopic data and chemical degradation. Basiliskamides A (1) and B (g) show potent in vitro anti-Candida, activity.

URL<Go to ISI>://000178935100011