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Trisphaerolide A, a novel polyketide from the Dominican sponge Erylus trisphaerus

TitleTrisphaerolide A, a novel polyketide from the Dominican sponge Erylus trisphaerus
Publication TypeJournal Article
Year of Publication2003
Authorsvan Altena, I, Van Soest, R, Roberge, M, Andersen, RJ
JournalJournal of Natural Products
Volume66
Pagination561-563
Date PublishedApr
Type of ArticleArticle
ISBN Number0163-3864
Keywordsbiosynthesis, CELL-CYCLE, DNA-DAMAGE CHECKPOINT, INHIBITION, ISOGRANULATIMIDE
Abstract

The structure of trisphaerolide A (1), a mildly cytotoxic metabolite isolated from extracts of the marine sponge Erylus trisphaerus collected in Dominica, has been elucidated by detailed analysis of spectroscopic data. Trisphaerolide A (1) has a putative polyketide biogenesis, incorporating a rare variant on the standard pathway, which involves the addition of methyl branches arising from C-2 carbons of acetate units to chain carbons that arise from C-1 of acetate units.

URL<Go to ISI>://000182562800025