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TRIDIDEMNIC ACID-A AND ACID-B, AROMATIC ALKALOIDS FROM THE NORTHEASTERN PACIFIC ASCIDIAN TRIDIDEMNUM SP

TitleTRIDIDEMNIC ACID-A AND ACID-B, AROMATIC ALKALOIDS FROM THE NORTHEASTERN PACIFIC ASCIDIAN TRIDIDEMNUM SP
Publication TypeJournal Article
Year of Publication1992
AuthorsDe Silva, ED, Miao, SC, Andersen, RJ, Schultz, LW, Clardy, J
JournalTetrahedron Letters
Volume33
Pagination2917-2920
Date PublishedMay
Type of ArticleArticle
ISBN Number0040-4039
KeywordsALKALOID, ASCIDIAN, TRIDIDEMNUM
Abstract

Two new aromatic alkaloids, trididemnic acids A (1) and B (2), have been isolated from the marine ascidian Trididemnum sp. The structures of 1 and 2 were solved by spectroscopic analysis of their permethylated derivatives 4 and 5. Single crystal x-ray diffraction analysis of 4 confirmed the structures. An interesting retro-Fries rearrangement reaction, involving the conversion of 3 to 8 under bromination conditions, was also discovered.

URL<Go to ISI>://A1992HV88700002