Research & Faculty

Default Header Image

Total synthesis of topopyrones B and D

TitleTotal synthesis of topopyrones B and D
Publication TypeJournal Article
Year of Publication2006
AuthorsTan, JS, Ciufolini, MA
JournalOrganic Letters
Volume8
Pagination4771-4774
Date PublishedOct
Type of ArticleArticle
ISBN Number1523-7060
KeywordsDIRECTED ORTHO METALATION, HYPOXYXYLERONE, TOPOISOMERASE-I INHIBITORS
Abstract

We describe a straightforward synthesis of topopyrones B and D, which are potent and selective inhibitors of topoisomerase I. The chemistry should be suitable for additional structure-activity relationship (SAR) work.

URL<Go to ISI>://000241030900026