|Title||Total synthesis of streptonigrone|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Chan, BK, Ciufolini, MA|
|Journal||Journal of Organic Chemistry|
A total synthesis of streptonigrone, 1, is described, which incorporates a one-step synthesis of substituted pyridones devised in our laboratory. Other aspects of the synthesis that differentiate the present approach from previous ones are the use of a Conrad - Limpach reaction, rather than the customary Friedlander methodology, to assemble the quinoline segment of 1, and the implementation of an anionic sequence for the functionalization of a key pyridone intermediate.
|URL||<Go to ISI>://000250344300040|