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Total synthesis of streptonigrone

TitleTotal synthesis of streptonigrone
Publication TypeJournal Article
Year of Publication2007
AuthorsChan, BK, Ciufolini, MA
JournalJournal of Organic Chemistry
Volume72
Pagination8489-8495
Date PublishedOct
ISBN Number0022-3263
Abstract

A total synthesis of streptonigrone, 1, is described, which incorporates a one-step synthesis of substituted pyridones devised in our laboratory. Other aspects of the synthesis that differentiate the present approach from previous ones are the use of a Conrad - Limpach reaction, rather than the customary Friedlander methodology, to assemble the quinoline segment of 1, and the implementation of an anionic sequence for the functionalization of a key pyridone intermediate.

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