Research & Teaching Faculty

Default Header Image

Total synthesis of streptonigrone

TitleTotal synthesis of streptonigrone
Publication TypeJournal Article
Year of Publication2007
AuthorsChan, BK, Ciufolini, MA
JournalJournal of Organic Chemistry
Date PublishedOct
ISBN Number0022-3263

A total synthesis of streptonigrone, 1, is described, which incorporates a one-step synthesis of substituted pyridones devised in our laboratory. Other aspects of the synthesis that differentiate the present approach from previous ones are the use of a Conrad - Limpach reaction, rather than the customary Friedlander methodology, to assemble the quinoline segment of 1, and the implementation of an anionic sequence for the functionalization of a key pyridone intermediate.

URL<Go to ISI>://000250344300040