|Title||Total Synthesis of Cladoniamide G|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Loosley, BC, Andersen, RJ, Dake, GR|
|Date Published||MAR 1|
The total synthesis of cladoniamide G, a cytotoxic compound against MCF-7 breast cancer cells (10 mu g/mL), was accomplished. Key steps in the sequence include oxidative dimerization of 3-acetoxy-5-chloroindole and a tandem process incorporating three steps: bimolecular carbonyl addition, lactam formation, and carbamate removal.