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Total Synthesis of Cladoniamide G

TitleTotal Synthesis of Cladoniamide G
Publication TypeJournal Article
Year of Publication2013
AuthorsLoosley, BC, Andersen, RJ, Dake, GR
JournalORGANIC LETTERS
Volume15
Pagination1152-1154
Date PublishedMAR 1
ISSN1523-7060
Abstract

The total synthesis of cladoniamide G, a cytotoxic compound against MCF-7 breast cancer cells (10 mu g/mL), was accomplished. Key steps in the sequence include oxidative dimerization of 3-acetoxy-5-chloroindole and a tandem process incorporating three steps: bimolecular carbonyl addition, lactam formation, and carbamate removal.

DOI10.1021/ol400055v