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TERPENOID METABOLITES FROM SKIN EXTRACTS OF 4 SRI-LANKAN NUDIBRANCHS IN THE GENUS CHROMODORIS

TitleTERPENOID METABOLITES FROM SKIN EXTRACTS OF 4 SRI-LANKAN NUDIBRANCHS IN THE GENUS CHROMODORIS
Publication TypeJournal Article
Year of Publication1991
AuthorsDe Silva, ED, Morris, SA, Miao, SC, Dumdei, E, Andersen, RJ
JournalJournal of Natural Products
Volume54
Pagination993-997
Date PublishedJul-Aug
Type of ArticleArticle
ISBN Number0163-3864
KeywordsCONSTITUENTS, REARRANGED SPONGIAN DITERPENES
Abstract

The skin extracts of four species of Sri Lankan dorid nudibranchs belonging to the genus Chromodoris have been found to contain diterpenoids. Extracts of Chromodoris gleneii contained dendrillolide A [1], 12-desacetoxyshahamin C [2], and shahamin K [3]; extracts of Chromodoris geminus contained 12-beta, 15-alpha, 16-alpha-triacetoxyspongian [4], 6-alpha, 15-alpha, 16-alpha-triacetoxyspongian [5], and 6-alpha, 12-beta, 15-alpha, 16-alpha-tetraacetoxyspongian [6]; extracts of Chromodoris annulata contained shahamin F [7]; and extracts of Chromodoris inopinata contained aplyroseol 2 [8], the gamma-lactone 9, and spongian-16-one [10]. Compounds 3, 5, and 6 are new diterpenoid metabolites. The remaining diterpenoids 1, 2, 4, and 7-10 have been previously isolated from marine sponges or other nudibranchs.

URL<Go to ISI>://A1991GF52600011