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Synthesis of pelorol and analogues: Activators of the inositol 5-phosphatase SHIP

TitleSynthesis of pelorol and analogues: Activators of the inositol 5-phosphatase SHIP
Publication TypeJournal Article
Year of Publication2005
AuthorsYang, L, Williams, DE, Mui, A, Ong, C, Krystal, G, Van Soest, R, Andersen, RJ
JournalOrganic Letters
Volume7
Pagination1073-1076
Date PublishedMar
Type of ArticleArticle
ISBN Number1523-7060
KeywordsCELLS, METABOLITE, MICE, SPONGE DACTYLOSPONGIA-ELEGANS
Abstract

A screening program designed to find new antiinflammatory agents has identified the sponge meroterpenoid pelorol (1) as an in vitro activator of the inositol-5-phosphatase SHIP. Pelorol (1) and several functional group analogues have been synthesized from sclareolide (4).

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