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Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A

TitleSynthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A
Publication TypeJournal Article
Year of Publication2008
AuthorsCarr, G, Chung, MKW, Mauk, AG, Andersen, RJ
JournalJournal of Medicinal Chemistry
Volume51
Pagination2634-2637
Date PublishedMay
Type of ArticleArticle
ISBN Number0022-2623
KeywordsCANCER, CATABOLISM, CELLS, chemotherapy, EXPRESSION, IDO, IMMUNE TOLERANCE, MECHANISM, SMALL-MOLECULE INHIBITORS, TRYPTOPHAN DEGRADATION
Abstract

Synthetic analogues of the sponge natural product exiguamine A (3) have been prepared and evaluated for their ability to inhibit indoleamine 2,3-dioxygenase in vitro.

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