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Synthesis, characterization, and evaluation of the antimicrobial potential of copper(II) coordination complexes with quinolone and p-xylenyl-linked quinolone ligands

TitleSynthesis, characterization, and evaluation of the antimicrobial potential of copper(II) coordination complexes with quinolone and p-xylenyl-linked quinolone ligands
Publication TypeJournal Article
Year of Publication2016
AuthorsMjos, KDralle, Polishchuk, E, Abrams, MJ, Orvig, C
JournalJ. Inorg. Biochem.
Volume162
Pagination280 - 285
ISSN0162-0134
Keywordsp-xylenyl-crosslinkage
Abstract

Abstract The antimicrobial properties of copper have been known to mankind since the ancient times. In a coordination chemistry approach to develop novel antimicrobial agents, the quinolone antimicrobial agents ciprofloxacin (Hcipro) and pipemidic acid (Hpia), as well as dimers thereof (piperazinyl-linked with a p-xylenyl moiety) were complexed with copper(II). The synthesis and antimicrobial evaluation of bis(ciprofloxacino)copper(II) [Cu(cipro)2], bis(pipemido)copper(II) [Cu(pia)2], and the corresponding dimer complexes, [Cu2(ciproXcipro)2] and [Cu2(piaXpia)2], are reported. No combinational or synergistic effect between copper(II) and the respective quinolone ligands was observed in vitro.

URLhttp://www.sciencedirect.com/science/article/pii/S0162013416300526
DOI10.1016/j.jinorgbio.2016.02.026
Refereed DesignationRefereed