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Studies toward soraphen A: An aldol-metathesis avenue to the macrocyclic framework

TitleStudies toward soraphen A: An aldol-metathesis avenue to the macrocyclic framework
Publication TypeJournal Article
Year of Publication2006
AuthorsVincent, G, Mansfield, DJ, Vors, JP, Ciufolini, MA
JournalOrganic Letters
Volume8
Pagination2791-2794
Date PublishedJun
Type of ArticleArticle
ISBN Number1523-7060
KeywordsALPHA-HYDROXYALLYLATION, ANTIFUNGAL, CARBONYL-COMPOUNDS, CHIRAL ALDEHYDES, ENANTIOSELECTIVE SYNTHESIS, GLIDING BACTERIA, MACROLIDE, OLEFIN METATHESIS, ORGANIC-SYNTHESIS, SILYL ETHERS, STEREOSELECTIVE SYNTHESIS
Abstract

We describe a convergent approach to soraphen A, 1, that involves coupling of two fragments by an aldol condensation - olefin metathesis sequence. This route permits rapid access to congeners of 1.

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