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Studies of a benzoporphyrin derivative with Pluronics

TitleStudies of a benzoporphyrin derivative with Pluronics
Publication TypeJournal Article
Year of Publication2002
AuthorsHioka, N, Chowdhary, RK, Chansarkar, N, Delmarre, D, Sternberg, E, Dolphin, D
JournalCanadian Journal of Chemistry-Revue Canadienne De Chimie
Volume80
Pagination1321-1326
Date PublishedOct
Type of ArticleArticle
ISBN Number0008-4042
KeywordsAGGREGATION, AQUEOUS-SOLUTIONS, block copolymers, BPD, COPOLYMERS, DYNAMICS, formulation, micelles, PHOTODYNAMIC THERAPY, photodynamic therapy (PDT), PHOTOSENSITIZERS, photosensitizing drug, Pluronic, poloxamers, porphyrins, SURFACTANTS, THERMODYNAMICS
Abstract

The synthetic route for the benzoporphyrin derivatives produces two regioisomers in equimolar quantities (ring A and B isomers). A derivative of the A-ring product, BPD-MA (benzoporphyrin-derivative monoacid ring A, verteporfin), has recently been approved in North America and Europe for the treatment of age-related macular degeneration. The B-ring isomers, contrary to the A-ring isomers, exhibit high aggregation in many formulations, which results in inadequate drug delivery for clinical uses. To avoid aggregation, a non-ionic surfactant polymer such as a Pluronic - poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) - may be used as a formulation excipient. The triblock polymer investigated here is designated P123 (or poloxamer 403). When used to formulate a monoacid benzoporphyrin B-ring derivative (2), a critical micelle concentration of P123 in water occurred at approximately 0.015 to 0.03%. The apparent pK(a) of compound 2 was dependent on its concentration in P123, and decreased as the molar ratio (P123:2) increased. High concentrations of P123 and neutral pH were found to be the best conditions to maintain the drug in its monomeric form. Kinetic studies suggest that the aggregate of 2 contains several molecules, and is formed by a catalyzed self-assembly process. Samples with 1 mg mL(-1) of drug, at pH = 7.4, and 4.8% of Pluronic showed satisfactory capacity to load and keep monomers stable. This formulation has potential PDT applications.

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