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THE STRUCTURE AND PARTIAL SYNTHESIS OF IMBRICATINE, A BENZYLTETRAHYDROISOQUINOLINE ALKALOID FROM THE STARFISH DERMASTERIAS-IMBRICATA

TitleTHE STRUCTURE AND PARTIAL SYNTHESIS OF IMBRICATINE, A BENZYLTETRAHYDROISOQUINOLINE ALKALOID FROM THE STARFISH DERMASTERIAS-IMBRICATA
Publication TypeJournal Article
Year of Publication1991
AuthorsBurgoyne, DL, Miao, S, Pathirana, C, Andersen, RJ, Ayer, WA, Singer, PP, Kokke, W, Ross, DM
JournalCanadian Journal of Chemistry-Revue Canadienne De Chimie
Volume69
Pagination20-27
Date PublishedJan
Type of ArticleArticle
ISBN Number0008-4042
KeywordsALKALOID, ASTEROID, IMBRICATINE, METABOLITE
Abstract

The structure of imbricatine (1), a cytotoxic metabolite of the starfish Dermasterias imbricata, has been determined by spectroscopic analysis and chemical degradation. Synthesis of model compounds 7 and 18 provided evidence for the absolute configuration and constitution of the benzyltetrahydroisoquinoline substructure of imbricatine.

URL<Go to ISI>://A1991EW99100004