|Title||Strongylophorine-26, an inhibitor of cancer cell invasion: SAR revealed by synthesis of analogues|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||Warabi, K, Patrick, BO, Austin, P, Roskelley, CD, Roberge, M, Andersen, RJ|
|Journal||Journal of Natural Products|
The absolute configuration of strongylophorine-26 (1) was determined to be 4S, 5R, 8R, 9S, 10S, 13S, 14S by single-crystal X-ray diffraction analysis of the derivative 7 prepared from the co-occurring metabolite strongylophorine-8 (4) and chemical interconversion to the bislactone 8. Synthetic analogues (+)- and (-)-3 have been prepared in order to explore the structure-activity relationship for the anti-invasion pharmacophore of stronglylophorine-26. These studies revealed the unanticipated importance of the A ring lactone moiety for the anti-invasion activity of 1.
|URL||<Go to ISI>://000246764300003|