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Spirastrellolide B reveals the absolute configuration of the spirastrellolide macrolide core

TitleSpirastrellolide B reveals the absolute configuration of the spirastrellolide macrolide core
Publication TypeJournal Article
Year of Publication2007
AuthorsWarabi, K, Williams, DE, Patrick, BO, Roberge, M, Andersen, RJ
JournalJournal of the American Chemical Society
Volume129
Pagination508-509
Date PublishedJan
ISBN Number0002-7863
Abstract

The new macrolide spirastrellolide B (5) has been isolated from extracts of the marine sponge Spirastrella coccinea collected in Dominica. Chemical transformations of spirastrellolide B have converted it to a bromine-containing crystalline derivative 8 that has a truncated side chain. Singlecrystal X-ray diffraction analysis of the derivative 8 has revealed the absolute configuration of the macrolide core of spirstrellolide B to be 3R,7S,9S,11S,13R,14S,17S,20S,21R,22S,23S,24S,27R,29S,31R,34S,35R,37S,38S .

URL<Go to ISI>://000243503700028