|Title||Spiculoic acids A and B, new polyketides isolated from the Caribbean marine sponge Plakortis angulospiculatusi|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Huang, XH, Van Soest, R, Roberge, M, Andersen, RJ|
|Type of Article||Article|
|Keywords||HALICHONDRIOIDES, PAPUA-NEW-GUINEA, PLAKOTENIN|
Two novel polyketides, spiculoic acids A (1) and B (2), have been isolated from extracts of the Caribbean marine sponge Plakortis angulospiculatus. The structures of 1 and 2 were elucidated by detailed analysis of spectroscopic data. Spiculoic acid A (1) showed in vitro cytotoxicity against human breast cancer MCF-7 cells. It has a putative polyketide biogenetic origin that involves incorporation of four butyrate units and a Diels Alderase catalyzed intramolecular [4 + 2] cycloaddition reaction.
|URL||<Go to ISI>://000187790500020|