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Spiculoic acids A and B, new polyketides isolated from the Caribbean marine sponge Plakortis angulospiculatusi

TitleSpiculoic acids A and B, new polyketides isolated from the Caribbean marine sponge Plakortis angulospiculatusi
Publication TypeJournal Article
Year of Publication2004
AuthorsHuang, XH, Van Soest, R, Roberge, M, Andersen, RJ
JournalOrganic Letters
Volume6
Pagination75-78
Date PublishedJan
Type of ArticleArticle
ISBN Number1523-7060
KeywordsHALICHONDRIOIDES, PAPUA-NEW-GUINEA, PLAKOTENIN
Abstract

Two novel polyketides, spiculoic acids A (1) and B (2), have been isolated from extracts of the Caribbean marine sponge Plakortis angulospiculatus. The structures of 1 and 2 were elucidated by detailed analysis of spectroscopic data. Spiculoic acid A (1) showed in vitro cytotoxicity against human breast cancer MCF-7 cells. It has a putative polyketide biogenetic origin that involves incorporation of four butyrate units and a Diels Alderase catalyzed intramolecular [4 + 2] cycloaddition reaction.

URL<Go to ISI>://000187790500020