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A SARS-coronovirus 3CL protease inhibitor isolated from the marine sponge Axinella cf. corrugata: Structure elucidation and synthesis

TitleA SARS-coronovirus 3CL protease inhibitor isolated from the marine sponge Axinella cf. corrugata: Structure elucidation and synthesis
Publication TypeJournal Article
Year of Publication2007
Authorsde Lira, SP, Seleghim, MHR, Williams, DE, Marion, F, Hamill, P, Jean, F, Andersen, RJ, Hajdu, E, Berlinck, RGS
JournalJournal of the Brazilian Chemical Society
Volume18
Pagination440-443
ISBN Number0103-5053
Abstract

Two coumarin derivatives, esculetin-4-carboxylic acid methyl ester (1) and esculetin-4-carboxylic acid ethyl ester (2), have been isolated from the marine sponge Axinella cf. corrugata. Structure determination included analysis of spectroscopic data and total synthesis of compound 2. These are the first coumarin derivatives isolated from a marine sponge. The ethyl ester 2 was found to be an in vitro inhibitor of SARS 3CL-protease and an effective inhibitor of SARS-CoV replication in Vero cells at non-cytotoxic concentrations.

URL<Go to ISI>://000246443800029