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RUBROLIDES-A-H, METABOLITES OF THE COLONIAL TUNICATE RITTERELLA-RUBRA

TitleRUBROLIDES-A-H, METABOLITES OF THE COLONIAL TUNICATE RITTERELLA-RUBRA
Publication TypeJournal Article
Year of Publication1991
AuthorsMiao, SC, Andersen, RJ
JournalJournal of Organic Chemistry
Volume56
Pagination6275-6280
Date PublishedOct
Type of ArticleArticle
ISBN Number0022-3263
KeywordsC-13 ASSIGNMENTS, CARIBBEAN TUNICATE, ECTEINASCIDIA-TURBINATA, H-1, MARINE NATURAL-PRODUCTS, NMR, SIGILLINOIDES
Abstract

Rubrolides A (1) to H (8), a new family of biologically active tunicate metabolites, have been isolated from Ritterella rubra. The structures of the rubrolides were solved by a combination of spectroscopic analysis and chemical interconversions. Rubrolides B (2) and H (8) represent some of the first chlorinated metabolites known from tunicates. The rubrolides are potent in vitro antibiotics and they show moderate but selective inhibition of protein phosphatases 1 and 2A.

URL<Go to ISI>://A1991GM57600012