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A Route to the Heterocyclic Cluster of the E-Series of Thiopeptide Antibiotics

TitleA Route to the Heterocyclic Cluster of the E-Series of Thiopeptide Antibiotics
Publication TypeJournal Article
Year of Publication2015
AuthorsHwang, H-J, Ciufolini, MA
JournalJOURNAL OF ORGANIC CHEMISTRY
Volume80
Pagination4184-4188
Date PublishedAPR 17
ISSN0022-3263
Abstract

A concise route to the 3-hydroxypyridine core of thiopeptide antibiotics such as nocathiacin is described. Key phases of the sequence involve a modified Hantzsch pyridine construction and a chemoselective Peng deprotection of a phenolic MOM ether.

DOI10.1021/acs.joc.5b00315