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Rolloamides A and B, Cytotoxic Cyclic Heptapeptides Isolated from the Caribbean Marine Sponge Eurypon laughlini

TitleRolloamides A and B, Cytotoxic Cyclic Heptapeptides Isolated from the Caribbean Marine Sponge Eurypon laughlini
Publication TypeJournal Article
Year of Publication2009
AuthorsWilliams, DE, Yu, K, Behrisch, HW, Van Soest, R, Andersen, RJ
JournalJournal of Natural Products
Volume72
Pagination1253-1257
Date PublishedJul
Type of ArticleArticle
ISBN Number0163-3864
KeywordsNATURAL-PRODUCTS, OCTAPEPTIDE, PEPTIDES, PORIFERA, PROLINE, STYLOTELLA-AURANTIUM
Abstract

Two cyclic heptapeptides, rolloamides A (1) and B (2), have been isolated from the Dominican marine sponge Eurypon laughlini. The structures of 1 and 2 were elucidated by a combination of spectroscopic analyses and chemical degradation. Rolloamide A (1), which was found to exist as two distinct conformers in C5D5N, exhibits growth suppressive activity against a panel of histologically diverse cancer cell lines.

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