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Review of recent developments in determining volatile organic compounds in exhaled breath as biomarkers for lung cancer diagnosis

TitleReview of recent developments in determining volatile organic compounds in exhaled breath as biomarkers for lung cancer diagnosis
Publication TypeJournal Article
Year of Publication2017
AuthorsZhou, J, Huang, Z-A, Kumar, U, Chen, DDY
JournalAnalytica Chimica Acta
Pagination-
ISSN0003-2670
KeywordsBiomarker
Abstract

Abstract Lung cancer is the most common cause of cancer deaths, its global incidence is rising, and continuing rises are predicted. The potential to diagnose lung cancers based on the determination of volatile organic compounds (VOCs) in human breath has been attracting increasing attention with the development of new techniques and methodologies. However, despite many reports of \{VOC\} profiling in lung cancer patients, little is known about how specific biomarkers relate to the biochemical pathways involved in lung cancer development, and there is still no reliable method for diagnosing lung cancer at the early stages. This review summarizes some of the latest methods used for monitoring biomarkers in lung cancer patients, which could be applicable for clinical diagnosis. Techniques for capturing and pre-concentrating biomarkers, and the technologies used for subsequently determining them, are also discussed.

URLhttp://www.sciencedirect.com/science/article/pii/S000326701731070X
DOI10.1016/j.aca.2017.09.021