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Quantitative assay fdr epinephrine in dental anesthetic solutions by capillary electrophoresis

TitleQuantitative assay fdr epinephrine in dental anesthetic solutions by capillary electrophoresis
Publication TypeJournal Article
Year of Publication1998
AuthorsBritz-McKibbin, P, Kranack, AR, Paprica, A, Chen, DDY
JournalAnalyst
Volume123
Pagination1461-1463
Date PublishedJul
Type of ArticleArticle
ISBN Number0003-2654
Keywordsanalyte focusing, capillary electrophoresis, CHROMATOGRAPHY, dental anesthetic solutions, EPINEPHRINE, INJECTION, LIDOCAINE, SAMPLES, STACKING, TETRACAINE, ZONE ELECTROPHORESIS
Abstract

A simple and robust method for the separation and quantification of epinephrine in dental anesthetic solutions was developed. The method allows the direct injection of high salt solutions without Sample pre-treatment. Large sample plugs (5.7% of the total capillary length) are used for epinephrine determination by selective analyte focusing in capillary electrophoresis, The concentration detection limit for epinephrine is about 5.0 x 10(-7) M (90 ng ml(-1)) with a commercial UV detector. The separation protocol was validated in terms of its precision, linearity, accuracy and specificity.

URL<Go to ISI>://000074920200007