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Pyrodysinoic Acid Derivatives from the Marine Sponge Dysidea robusta

TitlePyrodysinoic Acid Derivatives from the Marine Sponge Dysidea robusta
Publication TypeJournal Article
Year of Publication2009
AuthorsWilliams, DE, Marques, SO, Hajdu, E, Peixinho, S, Andersen, RJ, Berlinck, RGS
JournalJournal of Natural Products
Volume72
Pagination1691-1694
Date PublishedSep
Type of ArticleArticle
ISBN Number0163-3864
KeywordsAMINO-ACID, biosynthesis, CELLULAR-ORIGIN, DENDROLASIN, DYSIHERBAINE, GENUS DYSIDEA, HERBACEA, METABOLITES, NATURAL-PRODUCTS, SESQUITERPENES
Abstract

Three new nitrogen-containing terpenes related to pyrodysinoic acid (1) have been isolated from the sponge Dysidea robusta collected in Brazil. Isopyrodysinoic acid (2), 13-hydroxyisopyrodysinoic acid (3), and pyrodysinoic acid B (4) were obtained from the crude extract of D. robusta and identified by analysis of spectroscopic data. Pyrodysinoic acid B (4) is the first furodysin or furodysinin sesquiterpene derivative with a trans junction between the two six-membered rings of the 1,2,3,4,4a,7,8,8a-octahydro-1,1,6-trimethylnaphthalene moiety.

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