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Protein phosphatase inhibitors isolated from Spongia irregularis collected in Papua New Guinea

TitleProtein phosphatase inhibitors isolated from Spongia irregularis collected in Papua New Guinea
Publication TypeJournal Article
Year of Publication2007
AuthorsCarr, G, Raszek, M, Van Soest, R, Matainaho, T, Shopik, M, Holmes, CFB, Andersen, RJ
JournalJournal of Natural Products
Volume70
Pagination1812-1815
Date PublishedNov
ISBN Number0163-3864
Abstract

Irregularasulfate (1), a new nitrogen-containing sesterterpenoid, and the known sesterterpenoids hipposulfate C (2), halisulfate-7 (3), and igernellin (4), have been isolated from the marine sponge Spongia irregularis collected in Papua New Guinea. The structure of I was elucidated via analysis of its spectroscopic data. Sesterterpenoids 1, 2, and 3 are moderate inhibitors of the catalytic subunits of the mammalian Ser/Thr protein phosphatases calcineurin, PP-1, and PP-2A. The phosphate analogue of 3 and the thiophosphate analogue of 2 have been prepared from the corresponding natural products and evaluated for their ability to inhibit the phosphatase activity of calcineurin.

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