Pierre Kennepohl

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Pierre Kennepohl

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Research and Teaching Interests

 My research centres on probing the relationship between electronic structure and reactivity in catalytic systems. Emphasis is placed on the application of element-specific spectroscopic techniques such as X-ray Absorption Spectroscopy (XAS) and X-ray Emission Spectroscopy (XES) as a means of generating experimentally-validated electronic and geometric structure descriptions of catalytically relevant species.  

 

Recent investigations by Thamy Sriskandakumar, in collaboration with Prof Peter J. Sadler and members of his group provided new insights into the possible mechanism of action of a series of potent cytotoxic ruthenium(II) arene complexes of interest as potential anticancer drugs. (see J. Am. Chem. Soc. 2009, 131(37), 13355–13361)

Other spectroscopic techniques (such as UV/Vis/NIR Absorption and EPR), as well as computational methods, are used as complementary methods to explore such species. We have varied interests in a number of areas spanning bioinorganic, organometallic, and physical inorganic chemistry. Specific projects are (as much as possible) tailored to the specific interests and strengths of students.

Contact

Real name: 
Email: 
Office Room Number(s): 
CHEM D314
Office Phone Number: 
604-822-3817
Lab Room: 
CHEM D428A
Fax Number: 
604-822-2847

Curriculum Vitae

B.Sc., Concordia - Canada Scholar (Nick Serpone, 1993)

Ph.D., Stanford - NSERC Centennial Scholar (Edward I Solomon, 2002)

PDF, Caltech (Harry B Gray & Adrian Ponce, 2002-3)

Publications

In Press

Mustoe, C. L. ; Yu, D. ; Gunabalasingam, M. ; Patrick, B. O. ; Kennepohl, P. Probing Covalency In Halogen Bonds Through Donor K-Edge X-Ray Absorption Spectroscopy: Polyhalides As Coordination Complexes. Faraday Discussions In Press.

2016

Desnoyer, A. N. ; Behyan, S. ; Patrick, B. O. ; Dauth, A. ; Love, J. A. ; Kennepohl, P. Reexamining Oxidation States During The Synthesis Of 2-Rhodaoxetanes From Olefins. Inorg. Chem. 2016, 55, 13-15.
Xue, W. ; Ruddick, J. N. R. ; Kennepohl, P. Solubilisation And Chemical Fixation Of Copper(Ii) In Micronized Copper Treated Wood. Dalton Trans. 2016, 45, 3679-3686.
Majhi, P. Kumar; Chow, K. C. F. ; Hsieh, T. H. H. ; Bowes, E. G. ; Schnakenburg, G. ; Kennepohl, P. ; Streubel, R. ; Gates, D. P. Even The Normal Is Abnormal: N-Heterocyclic Carbene C-2 Binding To A Phosphaalkene Without Breaking The P=C Pi-Bond. Chem.Commun. 2016, 52, 998-1001.

2015

Sriskandakumar, T. ; Behyan, S. ; Habtemariam, A. ; Sadler, P. J. ; Kennepohl, P. Electrophilic Activation Of Oxidized Sulfur Ligands And Implications For The Biological Activity Of Ruthenium(Ii) Arene Anticancer Complexes. Inorg. Chem. 2015, 54, 11574-11580.
Chong, E. ; Xue, W. ; Storr, T. ; Kennepohl, P. ; Schafer, L. L. Pyridonate-Supported Titanium(Iii). Benzylamine As An Easy-To-Use Reductant. Organometallics 2015, 34, 4941-4945.
Stirling, R. ; Ruddick, J. N. R. ; Xue, W. ; Morris, P. I. ; Kennepohl, P. Characterization Of Copper In Leachates From Acq- And Mcq-Treated Wood And Its Effects On Basidiospore Germination. Wood Fibre Chem. 2015, 47, 209-216.
Xue, W. ; Kennepohl, P. ; Ruddick, J. N. R. Reacted Copper(Ii) Concentrations In Earlywood And Latewood Of Micronized Copper-Treated Canadian Softwood Species. Holzforschung 2015, 69, 509-512.
Robinson, S. W. ; Mustoe, C. L. ; White, N. G. ; Brown, A. ; Thompson, A. L. ; Kennepohl, P. ; Beer, P. D. Evidence For Halogen Bond Covalency In Acyclic And Interlocked Halogen-Bonding Receptor Anion Recognition. J. Am. Chem. Soc. 2015, 137, 499-507.

2014

Drover, M. W. ; Beh, D. W. ; Kennepohl, P. ; Love, J. A. 3-Rhoda-1,2-Diazacyclopentanes: A Series Of Novel Metallacycle Complexes Derived From C-N Functionalization Of Ethylene. Chem. Eur. J. 2014, 20, 13345-13355.

2013

Chen, P. ; Gamelin, D. R. ; Kennepohl, P. Preface. Coord. Chem. Rev. 2013, 257, 1–2.
Keske, E. C. ; Zenkina, O. V. ; Asadi, A. ; Sun, H. ; Praetorius, J. M. ; Allen, D. P. ; Covelli, D. ; Patrick, B. O. ; Wang, R. ; Kennepohl, P. ; James, B. R. ; Crudden, C. M. Dioxygen Adducts Of Rhodium N-Heterocyclic Carbene Complexes. Dalton Trans. 2013, 42, 7414–23.

2012

Cipot-Wechsler, J. ; Covelli, D. ; Praetorius, J. M. ; Hearns, N. ; Zenkina, O. V. ; Keske, E. C. ; Wang, R. ; Kennepohl, P. ; Crudden, C. M. Synthesis And Characterization Of Cationic Rhodium Peroxo Complexes. Organometallics 2012, 31, 7306–7315.
Rueda-Becerril, M. ; Sazepin, C. Chatalova; Leung, J. Cho Tak; Okbinoglu, T. ; Kennepohl, P. ; Paquin, J. - F. ; Sammis, G. M. Fluorine Transfer To Alkyl Radicals. J. Am. Chem. Soc. 2012, 134, 4026–9.

2011

Martin-Diaconescu, V. ; Perepichka, I. ; D Bohle, S. ; Kennepohl, P. Electronic Structure Of S -Nitrosothiols From Sulfur K-Edge X-Ray Absorption Spectroscopy. Can. J. Chem. 2011, 89, 93–97.

2010

Delgado-Jaime, M. Ulises; Kennepohl, P. Development And Exploration Of A New Methodology For The Fitting And Analysis Of Xas Data. Journal of synchrotron radiation 2010, 17, 119–28.
Delgado-Jaime, M. Ulises; Mewis, C. Philip; Kennepohl, P. Blueprint Xas: A Matlab-Based Toolbox For The Fitting And Analysis Of Xas Spectra. J. Syncr. Rad. 2010, 17, 132–7.

2009

Bates, J. €I. ; Kennepohl, P. ; Gates, D. P. Abnormal Reactivity Of An N-Heterocyclic Carbene (Nhc) With A Phosphaalkene: A Route To A 4-Phosphino-Substituted Nhc. Angew. Chem. Int. Ed. 2009, 48, 9844–9847.
Kennepohl, P. ; Wasinger, E. C. ; George, S. DeBeer X-Ray Spectroscopic Approaches To The Investigation And Characterization Of Photochemical Processes. J. Syncr. Rad. 2009, 16, 484–8.
Sriskandakumar, T. ; Petzold, H. ; Bruijnincx, P. C. A. ; Habtemariam, A. ; Sadler, P. J. ; Kennepohl, P. Influence Of Oxygenation On The Reactivity Of Ruthenium-Thiolato Bonds In Arene Anticancer Complexes: Insights From Xas And Dft. J. Am. Chem. Soc. 2009, 131, 13355–61.

2008

Praetorius, J. M. ; Allen, D. P. ; Wang, R. ; Webb, J. D. ; Grein, F. ; Kennepohl, P. ; Crudden, C. M. N-Heterocyclic Carbene Complexes Of Rh: Reaction With Dioxygen Without Oxidation. J. Am. Chem. Soc. 2008, 130, 3724–5.
Getty, K. ; Delgado-Jaime, M. Ulises; Kennepohl, P. Assignment Of Pre-Edge Features In The Ru K-Edge X-Ray Absorption Spectra Of Organometallic Ruthenium Complexes. Inorg. Chim. Acta 2008, 361, 1059.

2007

Martin-Diaconescu, V. ; Kennepohl, P. Sulfur K-Edge Xas As A Probe Of Sulfur-Centered Radical Intermediates. J. Am. Chem. Soc. 2007, 129, 3034–5.
Gilroy, J. B. ; McKinnon, S. D. J. ; Kennepohl, P. ; Zsombor, M. S. ; Ferguson, M. J. ; Thompson, L. K. ; Hicks, R. G. Probing Electronic Communication In Stable Benzene-Bridged Verdazyl Diradicals. J. Org. Chem. 2007, 72, 8062–8069.

2006

2005

Kennepohl, P. ; Neese, F. ; Schweitzer, D. ; Jackson, H. L. ; Kovacs, J. A. ; Solomon, E. I. Spectroscopy Of Non-Heme Iron Thiolate Complexes: Insight Into The Electronic Structure Of The Low-Spin Active Site Of Nitrile Hydratase. Inorg. Chem. 2005, 44, 1826–36.
Solomon, E. I. ; Basumallick, L. ; Chen, P. ; Kennepohl, P. Variable Energy Photoelectron Spectroscopy: Electronic Structure And Electronic Relaxation. Coord. Chem. Rev. 2005, 249, 229–253.

2004

Funk, T. ; Kennepohl, P. ; Di Bilio, A. J. ; Wehbi, Wa; Young, A. T. ; Friedrich, S. ; Arenholz, E. ; Gray, H. B. ; Cramer, S. P. X-Ray Magnetic Circular Dichroism Of Pseudomonas Aeruginosa Nickel(Ii) Azurin. J. Am. Chem. Soc. 2004, 126, 5859–66.

2003

1997

Westre, T. E. ; Kennepohl, P. ; DeWitt, J. G. ; Hedman, B. ; Hodgson, K. O. ; Solomon, E. I. A Multiplet Analysis Of Fe K-Edge 1S → 3D Pre-Edge Features Of Iron Complexes. J. Am. Chem. Soc. 1997, 119, 6297–6314.

1996

Holm, R. H. ; Kennepohl, P. ; Solomon, E. I. Structural And Functional Aspects Of Metal Sites In Biology. Chem. Rev. 1996, 96, 2239–2314.