Glenn SammisAssistant Professor
Office: 349 Chem/Phys
Office Phone: (604) 827-4080
Lab(s): Chemistry/Physics A402
Lab Phone(s): (604) 827-4442
FAX: (604) 822-2847
Email: gsammis@chem.ubc.ca
Curriculum Vitae: B.S. (honors), Stanford University (1999); Ph.D., Harvard University (Eric. N. Jacobsen, 2004); National Institutes of Health Postdoctoral Fellow, Princeton University (Erik. J. Sorensen, 2004-2006)
Organic:
Investigation of new methods for the syntheses of complex natural products, exploration of proposed biogenetic pathways through biomimetic synthesis, enantioselective synthesis of building blocks for total synthesis
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Research/Teaching Interests
Our research focuses on the development of new methods for the syntheses of architecturally complex natural products. This encompasses the use of organometallic reagents for the development of new bond construction techniques, the enantioselective synthesis of building blocks for total synthesis, and the development and evaluation of proposed biogenetic pathways through biomimetic synthesis. Central to efficient methods development is a fundamental understanding of reactivity and reaction mechanism. Reaction kinetics will therefore be fully integrated with all methodology development to maximize the reaction’s utility and efficiency.
Synthetic investigations into architecturally complex targets often lead to innovative and creative bond disconnections. All of our methodology projects are therefore inspired by natural products. For example, in the synthesis of bipinnatin I, a new transition metal-mediated furanylation will be explored to set the tricyclic core structure in a single transformation. This methodology will also be applied to the synthesis of other related bioactive targets, such as kallolide A and pinnatin A. New reactions for bond formation will also be studied in the total synthesis of maoecrystal V using a transition metal-mediated carbon-oxygen oxidative coupling reaction to synthesize maoecrystal’s complex polycyclic core. In addition, enantioselective Lewis acid catalysis will be investigated for the preparation of building blocks for the syntheses of highly oxygenated, stereochemically complex natural products, such as lingshiuiol and tetrafibricin. The fundamental objective of our research will be to develop versatile reactions for use in total synthesis.
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