|Title||OGA inhibition by GlcNAc-selenazoline|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Kim, EJu, Love, DC, Darout, E, Abdo, M, Rempel, B, Withers, SG, Rablen, PR, Hanover, JA, Knapp, S|
|Journal||BIOORGANIC & MEDICINAL CHEMISTRY|
|Date Published||OCT 1|
The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay. In human cells, however, the selenazoline shows comparable ability to induce hyper-O-GlcNAc-ylation, and the two show similar reduction of insulin-stimulated translocation of glucose transporter 4 in differentiated 3T3 adipocytes. (C) 2010 Elsevier Ltd. All rights reserved.