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Novel “bi-modal” H2dedpa derivatives for radio- and fluorescence imaging

TitleNovel “bi-modal” H2dedpa derivatives for radio- and fluorescence imaging
Publication TypeJournal Article
Year of Publication2016
AuthorsRamogida, CF, Murphy, L, Cawthray, JF, Ross, JD, Adam, MJ, Orvig, C
JournalJ. Inorg. Biochem.
Volume162
Pagination253 - 262
ISSN0162-0134
KeywordsSpheroids
Abstract

Abstract A novel pyridyl functionalized analog of the promising hexadentate 68Ga3 + chelate \{H2dedpa\} (N4O2, 1,2-[[6-carboxy-pyridin-2-yl]-methylamine]ethane) was successfully synthesized and characterized. This new bifunctional chelate (BFC) was used to prepare the first proof-of-principle bi-modal \{H2dedpa\} derivative for fluorescence and nuclear imaging. Two bi-modal \{H2dedpa\} derivatives were prepared: H2dedpa-propylpyr-FITC and H2dedpa-propylpyr-FITC-(N,N′-propyl-2-NI) (FITC = fluorescei

URLhttp://www.sciencedirect.com/science/article/pii/S0162013415301239
DOI10.1016/j.jinorgbio.2015.11.021
Refereed DesignationRefereed