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New Looks On Drug Discovery: DNA G-Quadruplex Ligands And Food Phenolic Derivatives That Made It To A Start-Up Company

Date: 
Thursday, September 19, 2019 - 18:30 to 19:30
Speaker: 
Dr Juan Carlos Morales Sánchez
Affiliation: 
Institute of Parasitology and Biomedicine "López-Neyra" (IPBLN), CSIC, Granada, Spain
Event Category: 
ODG - Organic Discussion Group
Location: 
Chemistry D300

Abstract:

G-quadruplexes (G4) are DNA secondary structures which play important roles in the regulation of gene expression in cells and have been proposed as therapeutic targets for different diseases. Design, synthesis and therapeutic evaluation of G4 ligands as anticancer and antiparasitic drugs will be discussed. Later, the synthesis of new phenolic derivatives as potential drugs for the treatment of retinal degenerative diseases will be presented. Finally, how the results from this research line have led to a new spin-off company will also be disclosed.