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NEAMPHINE, A SULFUR-CONTAINING AROMATIC HETEROCYCLE ISOLATED FROM THE MARINE SPONGE NEAMPHIUS-HUXLEYI

TitleNEAMPHINE, A SULFUR-CONTAINING AROMATIC HETEROCYCLE ISOLATED FROM THE MARINE SPONGE NEAMPHIUS-HUXLEYI
Publication TypeJournal Article
Year of Publication1991
AuthorsDe Silva, ED, Racok, JS, Andersen, RJ, Allen, TM, Brinen, LS, Clardy, J
JournalTetrahedron Letters
Volume32
Pagination2707-2710
Date PublishedJun
Type of ArticleArticle
ISBN Number0040-4039
KeywordsALKALOIDS, CYTOTOXIC, HETEROCYCLE, NITROGEN, SPONGE, SULFUR, TUNICATE
Abstract

The structure of neamphine (1), a cytotoxic metabolite of the marine sponge Neamphius huxleyi, has been solved by single crystal x-ray diffraction analysis. Neamphine (1) represents the first example, either from nature or synthesis, of the imidazo[4,5-e]-1,2-thiazine ring system.

URL<Go to ISI>://A1991FN52400003