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Multiple sprayer system for high-throughput electrospray ionization mass spectrometry

TitleMultiple sprayer system for high-throughput electrospray ionization mass spectrometry
Publication TypeJournal Article
Year of Publication2002
AuthorsSchneider, BB, Douglas, DJ, Chen, DDY
JournalRapid Communications in Mass Spectrometry
Volume16
Pagination1982-1990
Type of ArticleArticle
ISBN Number0951-4198
KeywordsARRAYS, capillary electrophoresis, INTERFACE, LIBRARIES, LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY, SEPARATE SAMPLE
Abstract

A multiple sprayer electrospray ion source for high-throughput analysis is described. The ion source is comprised of multiple electrospray capillaries, each with an ion lens located near the tip. The electric potentials applied to the ion lenses are used to control the sprayers. The use of ion lenses eliminates the need for mechanical blocking devices to selectively enable or disable the sprayers, and results in a less expensive and more reliable set-up. Sprayers can be enabled or disabled within approximately 50-250 ms when the lens potentials are controlled manually. For simultaneous operation of multiple electrospray capillaries, it is advantageous to orient the capillaries so that the spray from each passes directly in front of the entrance aperture of the mass spectrometer. Copyright (C) 2002 John Wiley Sons, Ltd.

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