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MOTUPORIN, A POTENT PROTEIN PHOSPHATASE INHIBITOR ISOLATED FROM THE PAPUA-NEW-GUINEA SPONGE THEONELLA-SWINHOEI GRAY

TitleMOTUPORIN, A POTENT PROTEIN PHOSPHATASE INHIBITOR ISOLATED FROM THE PAPUA-NEW-GUINEA SPONGE THEONELLA-SWINHOEI GRAY
Publication TypeJournal Article
Year of Publication1992
AuthorsDe Silva, ED, Williams, DE, Andersen, RJ, Klix, H, Holmes, CFB, Allen, TM
JournalTetrahedron Letters
Volume33
Pagination1561-1564
Date PublishedMar
Type of ArticleArticle
ISBN Number0040-4039
KeywordsBIOACTIVE MARINE METABOLITES, MICROCYSTIS-AERUGINOSA, PEPTIDE, TOXIN
Abstract

Motuporin (1), a cyclic pentapeptide that is a potent protein phosphatase-1 inhibitor and cytotoxin, has been isolated from the marine sponge Theonella swinhoei collected in Papua New Guinea. The structure of motuporin was elucidated by spectroscopic analysis and chemical degradation.

URL<Go to ISI>://A1992HJ78400009