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Molecular interaction in capillary electrophoresis

TitleMolecular interaction in capillary electrophoresis
Publication TypeJournal Article
Year of Publication2003
AuthorsGalbusera, C, Chen, DDY
JournalCurrent Opinion in Biotechnology
Volume14
Pagination126-130
Date PublishedFeb
Type of ArticleReview
ISBN Number0958-1669
KeywordsANALYTE MIGRATION BEHAVIOR, BINDING, CONSTANTS, ERROR PROPAGATION, HUMAN SERUM-ALBUMIN, MONTE-CARLO, RANGE, RECTANGULAR HYPERBOLAE, SIMULATION
Abstract

At the present time, affinity capillary electrophoresis is a well-established method for the measurement of binding constants involving 1:1 interactions. Many recent applications of this technique have illustrated its versatility. If affinity capillary electrophoresis is to be widely applied to the study of all types of interactions it is imperative that we consider that higher order interactions may be present. Applying proper equations or developing new models appropriate to the description of such systems is essential to obtaining reliable binding information.

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